DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Myo3a

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_680779.3	Gene:	Myo3a / 667663	MGIID:	2183924	Length:	1621	Species:	Mus musculus

Alignment Length:	344	Identity:	139/344 - (40%)
Similarity:	204/344 - (59%)	Gaps:	38/344 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLV-PVESDLHEIIKEISIMQQ-CDSPYVVRY 100
            |...::|:..:|:|:||.|:|.::|:|....|:|:: |:.....||..|.:|::. .|.|.|||:
Mouse    25 PSDTWEIIETIGKGTYGKVFKVLNKKSGQKAAVKILDPIHDIDEEIEAEYNILRTLSDHPNVVRF 89

  Fly   101 YGSYFKQ-----YDLWICMEYCGAGSVSDIMR---LRKKTLTEDEIATILSDTLQGLVYLHLRRK 157
            ||.|||:     ..||:.:|.|..|||:|:::   .|.:.::|..||.||.:.|.||.:||..:.
Mouse    90 YGIYFKKDKINGDKLWLVLELCNGGSVTDLVKGFLKRGERMSEPVIAYILHEALMGLQHLHSNKT 154

  Fly   158 IHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIE-----EIGYDCVA 217
            ||||:|..||||.|||..||.||||:.||:.|..:.||.:|||||||||||.     :..||...
Mouse   155 IHRDVKGNNILLTTEGGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPEVIACEQQLDTTYDARC 219

  Fly   218 DIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRA 282
            |.|||||||:|:.:|.||..|:|||||:|.||:.|||..|:|:.||.||.||:||||.|:.:.|.
Mouse   220 DTWSLGITAIELGDGDPPLAELHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRP 284

  Fly   283 TATELLEHEFIRNAKHRSIL--KPMLE---------ETCAIREQQ------RANRSFGGVLAASQ 330
            |.::||:|:||...:.:.::  |.::|         .|...|.::      ..|||.  :.:...
Mouse   285 TVSDLLKHKFITQIEGKDVILQKQLMEFIDIHQCLGSTEKARHERIHTKKGNLNRSL--ISSLKD 347

  Fly   331 AKSLAT----QENGMQQHI 345
            ...|||    .||.:.:|:
Mouse   348 VDDLATLDVLDENTVSEHL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	124/269 (46%)
		S_TKc	42..293	CDD:214567	123/265 (46%)
		Mst1_SARAH	608..655	CDD:288481
Myo3a	NP_680779.3	PKc_like	10..295	CDD:304357	124/269 (46%)
		S_TKc	29..295	CDD:214567	123/265 (46%)
		MYSc	345..1060	CDD:214580	6/22 (27%)
		MYSc_Myo3	360..1048	CDD:276830	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910