DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Stk25

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_067512.3	Gene:	Stk25 / 59041	MGIID:	1891699	Length:	426	Species:	Mus musculus

Alignment Length:	427	Identity:	172/427 - (40%)
Similarity:	235/427 - (55%)	Gaps:	73/427 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQCDSPYVVR 99
            ||::|..:.::|:||:|.|||.:...:..:||||::.:   |.::.:|.:||:::.||||||:.|
Mouse    16 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITR 80

  Fly   100 YYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKA 164
            |:|||.|...|||.|||.|.||..|:  |:...|.|..|||||.:.|:||.|||..|||||||||
Mouse    81 YFGSYLKSTKLWIIMEYLGGGSALDL--LKPGPLEETYIATILREILKGLDYLHSERKIHRDIKA 143

  Fly   165 ANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEM 229
            ||:||:.:|..||||||||||||||..||||.:|||||||||||::..||..||||||||||:|:
Mouse   144 ANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIEL 208

  Fly   230 AEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFI- 293
            |:|:||..::||||.:|:||:..||:..  ...|..|.:||..||.|:|..|.||.|||:|:||
Mouse   209 AKGEPPNSDLHPMRVLFLIPKNNPPTLE--GHHSKPFKEFVEACLNKDPRFRPTAKELLKHKFIT 271

  Fly   294 RNAKHRSILKPML------------EETCA-----------------------IREQQRANRSFG 323
            |..|..|.|..::            ||:.:                       ||....:....|
Mouse   272 RYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKG 336

  Fly   324 GVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTL 388
            ..|.:||..:...:.....|.::         |||...|||.::.         |.:.|   |::
Mouse   337 TALHSSQKPAEPIKRQPRSQCLS---------TLVRPVFGELKEK---------HKQSG---GSV 380

  Fly   389 GPGGLRNLSKAAAPAAASSAASPLDMPAVDSGTMVEL 425
              |.|..|..|.:.|..|       .|.:....||.|
Mouse   381 --GALEELENAFSLAEES-------CPGISDKLMVHL 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	138/257 (54%)
		S_TKc	42..293	CDD:214567	136/253 (54%)
		Mst1_SARAH	608..655	CDD:288481
Stk25	NP_067512.3	STKc_STK25	15..291	CDD:270810	144/278 (52%)
Stk25	NP_067512.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..354		8/62 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910