DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and MAP4K2

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_024304397.1	Gene:	MAP4K2 / 5871	HGNCID:	6864	Length:	860	Species:	Homo sapiens

Alignment Length:	436	Identity:	148/436 - (33%)
Similarity:	228/436 - (52%)	Gaps:	61/436 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE--SDLHEIIKEISIMQQCDSPYV 97
            ||.|...|:::.::|.|:||.||||....:|.:.|:|:|.::  .|:..:.:||:|:::|..|.|
Human     9 LQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNV 73

  Fly    98 VRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDI 162
            |.|.|||.:...||||||:||.||:.:|.. ....|.|.:||.:..:.|:||.:||.:.||||||
Human    74 VAYIGSYLRNDRLWICMEFCGGGSLQEIYH-ATGPLEERQIAYVCREALKGLHHLHSQGKIHRDI 137

  Fly   163 KAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---EEIGYDCVADIWSLGI 224
            |.||:||..:|..|||||||:|:||.::|||.:.||||:||||||.   .:.||:.:.|:|:|||
Human   138 KGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGI 202

  Fly   225 TALEMAEGKPPYGEIHPMRAIFMIPQK--PPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATEL 287
            ||:|:.|.:||...:|||||:.::.:.  .||..|:..||:..|..|:...|.|.|..|.||.:|
Human   203 TAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKL 267

  Fly   288 LEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFME 352
            |:|.|......|::|..:|::.                                          .
Human   268 LQHPFTTQQLPRALLTQLLDKA------------------------------------------S 290

  Fly   353 DP--GTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLR-NLSKAAAPAAASSAASPLDM 414
            ||  ||..||.. |.:.......|:.:..:.|..|.|  |..:: :..|..||....:  .||:.
Human   291 DPHLGTPSPEDC-ELETYDMFPDTIHSRGQHGPAERT--PSEIQFHQVKFGAPRRKET--DPLNE 350

  Fly   415 PAVDSGTMV---ELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYR 457
            |..:..|::   ||..:|...|..:..:.|.|.::..:.:..:|.|
Human   351 PWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQVPHRGR 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	115/261 (44%)
		S_TKc	42..293	CDD:214567	114/257 (44%)
		Mst1_SARAH	608..655	CDD:288481
MAP4K2	XP_024304397.1	STKc_MAP4K3_like	16..272	CDD:270788	114/256 (45%)
MAP4K2	XP_024304397.1	CNH	528..840	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910