Protein Alignment hpo and Stk3

DIOPT Version :10

• Sequence 1: NP_611427.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_062609.2
• Gene: Stk3 / 56274
• MGIID: 1928487
• Length: 497
• Species: Mus musculus
• Alignment Length: 667
• Identity: 309/667 - (46%)
• Similarity: 378/667 - (56%)
• Gaps: 188/667 - (28%)

  Fly    12 MKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE 76
            |:.|..|.|    |||||||:||.:.||:|||::.||||||||||:||:||||..:||||.||||
Mouse     1 MEQPPASKS----KLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE 61

  Fly    77 SDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATI 141
            |||.||||||||||||||||||:|||||||..||||.||||||||||||:|||.|||||||||||
Mouse    62 SDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATI 126

  Fly   142 LSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 206
            |..||:||.|||..|||||||||.||||||||:||||||||||||||||||||||||||||||||
Mouse   127 LKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 191

  Fly   207 VIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVS 271
            ||:||||:|||||||||||::|||||||||.:|||||||||||..|||:||:|:.||.:|.|||.
Mouse   192 VIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVK 256

  Fly   272 KCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIR-----EQQRANRSFGGVLAASQA 331
            |||||.|:.|||||:||:|.||:|||..|||:.::.|...|:     ||||....
Mouse   257 KCLVKSPEQRATATQLLQHPFIKNAKPVSILRDLIAEAMEIKAKRHEEQQRELEE---------- 311

  Fly   332 KSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNL 396
                .:||..:..:       |..|:|       :.||.|..||  .|...:.||
Mouse   312 ----EEENSDEDEL-------DSHTMV-------KTSSESVGTM--RATSTMSEG---------- 346

  Fly   397 SKAAAPAAASSAASPLDMPAVDSGTMVE-----LESNLGTMVINSDSDDSTTAKNNDD-QKPRNR 455
                                  :.||:|     |||:||||||||:.::....:..:| ...||.
Mouse   347 ----------------------AQTMIEHNSTMLESDLGTMVINSEEEEEEEEEEEEDGTMKRNA 389

  Fly   456 -----YRPQFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDL 515
                 .||.|:::||::                                              |.
Mouse   390 TSPQVQRPSFMDYFDKQ----------------------------------------------DF 408

  Fly   516 NNWEH-NMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGI 579
            .|..| |.:...::                                          ..||.....
Mouse   409 KNKSHENCDQSMRE------------------------------------------PGPMSNSVF 431

  Fly   580 PAAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAK 644
            |           .|..:..      :|:|:|||.|:.::|..||..:|..||.|||:|:::|:||
Mouse   432 P-----------DNWRVPQ------DGDFDFLKNLSLEELQMRLKALDPMMEREIEELHQRYSAK 479

  Fly   645 RQPIVDAMNAKRKRQQN 661
            ||||:|||:||::||||
Mouse   480 RQPILDAMDAKKRRQQN 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_611427.1	STKc_MST1_2	38..293	CDD:132943	207/254 (81%)
		SARAH_Hpo	606..661	CDD:439183	30/54 (56%)
Stk3	NP_062609.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		12/22 (55%)
		STKc_MST1_2	23..278	CDD:132943	207/254 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..343		15/71 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..394		5/25 (20%)
		SARAH_MST2	442..490	CDD:439182	25/47 (53%)