DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and si:zfos-2326c3.2

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_009306038.1	Gene:	si:zfos-2326c3.2 / 561669	ZFINID:	ZDB-GENE-091113-25	Length:	1165	Species:	Danio rerio

Alignment Length:	686	Identity:	193/686 - (28%)
Similarity:	296/686 - (43%)	Gaps:	183/686 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FKLKKLSEESL--LQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIK-E 85
            |....||...|  |:.|..:|:::..:|.|:||.|||..|.::..:.|||::.|..|..:.|| |
Zfish     5 FTTTSLSNIDLASLRDPAGIFELIEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEDEIKLE 69

  Fly    86 ISIMQ-QCDSPYVVRYYGSYFKQY------DLWICMEYCGAGSVSDIMRLRK-KTLTEDEIATIL 142
            |:::: ......:..|||::.|:.      .||:.|||||||||:|:::..| ..|.||.||.:.
Zfish    70 INMLKTHSHHRNIATYYGAFVKKSPAGQDDQLWLVMEYCGAGSVTDLLKKTKGNCLKEDWIAYVC 134

  Fly   143 SDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 207
            .:.|:||::||....||||||..|:||......||.||||:.||..|:.:|||.||||:||||||
Zfish   135 REVLRGLLHLHSHHVIHRDIKGQNVLLTENAEIKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEV 199

  Fly   208 I-----EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFI 267
            |     .:..||..:|:|||||||||||||.||..::|||||:|:||:.|||..:. .:||.:|.
Zfish   200 IACDENPDSTYDYRSDVWSLGITALEMAEGVPPLCDMHPMRALFLIPRNPPPKLKS-KKWSKKFQ 263

  Fly   268 DFVSKCLVKEPDDRATATELLEHEFIRNAKH----RSILKPMLEETCAIREQQRANRSFGGVLAA 328
            .||..||||....|.:...||.|.||::..:    |..||..|:.|...|:
Zfish   264 TFVDSCLVKNYLHRPSTETLLRHSFIKDLPNERQVRITLKDHLDRTRKRRQ-------------- 314

  Fly   329 SQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFG-EYQQSSASDATMIAHAEQGVDEGTLGPGG 392
                                           ||.| ||:.|.:.|      .:.|::|....|..
Zfish   315 -------------------------------EKDGKEYEYSGSED------EDDGINEEEGEPSS 342

  Fly   393 LRNLSKAAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYR 457
            :.||     |..:......|         .::.|:|..|.:|..       ..|.|:      |:
Zfish   343 IVNL-----PGESMLRREFL---------RLQQETNSQTQLIQQ-------VHNQDN------YK 380

  Fly   458 PQFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLN-NWEHN 521
            .|.|                          |::|::.||||:::::.|.|.....::.. .|...
Zfish   381 KQLL--------------------------ADRQKRIQQQQEERRRFEDHQERLLHETGVQWPEL 419

  Fly   522 MEMQFQQISAINQYGLQQHQQQQQ---------VLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQ 577
            .||.:|:.:.:.:...:.|::|.:         ...:..|.:||......|..|
Zfish   420 QEMLWQEETDLTEKSKRNHKKQPKDSEHHRTDVESASSNLFDEQAQGRKAQRTL----------- 473

  Fly   578 GIPAAAPAQPPPAYQNQ-------HMHTQS------HAYVEGEFEFLKFLTFDDLNQRLCNIDHE 629
                       |..|:|       |.|.|.      |..:.|:.|        .|...|.|:::
Zfish   474 -----------PRDQSQLLFLLHDHTHQQKSSRATPHDGLAGKLE--------SLETHLVNLNN- 518

  Fly   630 MELEIEQLNKKY--NAKRQPIVDAMNAKRKRQQNIN 663
            :.:.|..:..:.  .:...|...|:. :..:|.|:|
Zfish   519 LAVRIPHVQSRLGSGSNSSPCTPALQ-RAVKQPNMN 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	120/268 (45%)
		S_TKc	42..293	CDD:214567	119/264 (45%)
		Mst1_SARAH	608..655	CDD:288481	7/48 (15%)
si:zfos-2326c3.2	XP_009306038.1	PKc_like	9..289	CDD:304357	124/280 (44%)
		S_TKc	25..289	CDD:214567	119/264 (45%)
		CNH	847..1143	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910