DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and stk24a

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001103921.1	Gene:	stk24a / 555297	ZFINID:	ZDB-GENE-070424-52	Length:	415	Species:	Danio rerio

Alignment Length:	383	Identity:	156/383 - (40%)
Similarity:	233/383 - (60%)	Gaps:	19/383 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQCD 93
            ::|...|||:|..:.::|:||:|.|:|.:...:..:||||::.:   |.::.:|.:||:::.|||
Zfish     7 QNLKLDPEKLFTKLERIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEVEDIQQEITVLSQCD 71

  Fly    94 SPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKI 158
            |.::.:|:|||.|...|||.|||.|.||..|:  |....|.|..|||||.:.|:||.|||..:||
Zfish    72 SLFITKYFGSYLKDTKLWIIMEYLGGGSALDL--LGPGALDETHIATILREILKGLDYLHSEKKI 134

  Fly   159 HRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLG 223
            ||||||||:||:.:|..||||||||||||||..||||.:|||||||||||::..||..|||||||
Zfish   135 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSEYDSKADIWSLG 199

  Fly   224 ITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELL 288
            |||:|:|:|:||:.::|||:.:|:||::.||:..  ..::....:||..||.|:|:.|.||.|||
Zfish   200 ITAIELAKGEPPHSDLHPMKVLFLIPKENPPTLE--GNYNKALKEFVDACLNKDPNFRPTAKELL 262

  Fly   289 EHEFI-RNAKHRSILKPMLEETCAIR-EQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFM 351
            :|:.| |.:|..|.|..::::....: :|.|...|........:|...:..::.:...||::..:
Zfish   263 KHKLIVRYSKKTSYLMDLIDKYKKWKLKQAREESSSDSDSDEEEASGESVNDDWIFNTITESKPI 327

  Fly   352 EDPGTL----------VPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKA 399
            ::|..:          ||::.......|.|.......||.....|...||.|..|.:|
Zfish   328 QEPNRVLKPVENKPKKVPDRPKRSPSQSMSSIMSPLFAELKQKRGVYKPGVLDELKQA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	131/257 (51%)
		S_TKc	42..293	CDD:214567	128/253 (51%)
		Mst1_SARAH	608..655	CDD:288481
stk24a	NP_001103921.1	STKc_MST3_like	15..288	CDD:270786	134/276 (49%)
stk24a	NP_001103921.1	S_TKc	17..267	CDD:214567	128/253 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D967913at2759
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920