DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Stk39

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_062235.1	Gene:	Stk39 / 54348	RGDID:	621643	Length:	553	Species:	Rattus norvegicus

Alignment Length:	397	Identity:	134/397 - (33%)
Similarity:	200/397 - (50%)	Gaps:	64/397 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE---SDLHEIIKEISIMQQCDSPYVVRYYGS 103
            :::...:|.|:...|..|:.|.....||||.:.:|   :.:.|::|||..|.||..|.||.||.|
  Rat    72 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTS 136

  Fly   104 YFKQYDLWICMEYCGAGSVSDIMRL-------RKKTLTEDEIATILSDTLQGLVYLHLRRKIHRD 161
            :..:.:||:.|:....||:.||::.       :...|.|..|||||.:.|:||.|||...:||||
  Rat   137 FVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRD 201

  Fly   162 IKAANILLNTEGYAKLADFGVA------GQLTDTMAKRNTVIGTPFWMAPEVIEEI-GYDCVADI 219
            :||.||||..:|..::|||||:      |.:|.... |.|.:|||.||||||:|:: |||..||:
  Rat   202 LKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKV-RKTFVGTPCWMAPEVMEQVRGYDFKADM 265

  Fly   220 WSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFRE-------PDRWSTEFIDFVSKCLVKE 277
            ||.||||:|:|.|..||.:..||:.:.:..|..||:...       ..::...|...:|.||.|:
  Rat   266 WSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKD 330

  Fly   278 PDDRATATELLEHEFIRNAKHRS-ILKPMLEETCAIREQQRA----------------------- 318
            |..|.||.|||:.:|.:.||:|. :::.:|..|..|.::.:.
  Rat   331 PSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSD 395

  Fly   319 ----NRSFGGVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHA 379
                .:|..|..||||.||...:|...:  |:.||     |. :||   :.|..|..|:....:|
  Rat   396 DEMDEKSEEGKAAASQEKSRRVKEENPE--ISVNA-----GG-IPE---QIQSLSVHDSQGQPNA 449

  Fly   380 EQGVDEG 386
            .:...||
  Rat   450 NEDYREG 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	106/274 (39%)
		S_TKc	42..293	CDD:214567	106/274 (39%)
		Mst1_SARAH	608..655	CDD:288481
Stk39	NP_062235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		STKc_OSR1_SPAK	70..346	CDD:270787	106/274 (39%)
		S_TKc	72..346	CDD:214567	106/274 (39%)
		Interaction with RELT. /evidence=ECO:0000250\|UniProtKB:Q9Z1W9	319..544		40/149 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	369..375		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..431		13/68 (19%)
		Caspase cleavage related site	396..400		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910