DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Pak

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	323	Identity:	120/323 - (37%)
Similarity:	190/323 - (58%)	Gaps:	18/323 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SVVDMKSPNISSSCSFFKLKKLSEESLLQ---------PPEKVFDIMYKLGEGSYGSVYKAVHKE 63
            :|....:||..::.:  |.||:|:|.:|:         .|.:.:..|.|:|:|:.|:||.|:...
  Fly   525 AVAPAATPNTRAANA--KKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESS 587

  Fly    64 SSSIVAIKLVPVESDLHE--IIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIM 126
            :...||||.:.:.....:  ||.||.:|::...|.||.|..||....:||:.|||...||::|:
  Fly   588 TGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDV- 651

  Fly   127 RLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMA 191
             :.:..:.|.:||.:..:.||.|.:||..:.||||||:.||||..:|..||.|||...|::...:
  Fly   652 -VTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQS 715

  Fly   192 KRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSF 256
            ||.|::|||:||||||:....|....|:|||||.|:||.||:|||...:|::|:::|.....|..
  Fly   716 KRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEI 780

  Fly   257 REPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRAN 319
            :|.|:.|:.|.||:.:||..|.|.||:|.:||:|.|::.|:..:.|.|::   .|.:|..:.|
  Fly   781 KEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLI---MAAKEATKGN 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	104/256 (41%)
		S_TKc	42..293	CDD:214567	103/252 (41%)
		Mst1_SARAH	608..655	CDD:288481
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	105/261 (40%)
		S_TKc	566..817	CDD:214567	103/252 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438563
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940