DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Mekk1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster

Alignment Length:	300	Identity:	94/300 - (31%)
Similarity:	149/300 - (49%)	Gaps:	30/300 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KLGEGSYGSVYKAVHKESSSIVAIKLVPVESD----LHEIIKEISIMQQCDSPYVVRYYGSYFKQ 107
            |:|:|.:|.||.||:..:..::|:|.:.::..    |..:.:|:.|::......:|||||....:
  Fly  1287 KIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHR 1351

  Fly   108 YDLWICMEYCGAGSVSDIMRLR---KKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANI-L 168
            .:|.|.||.|..|::..::.|.   .:.||....|.:||    |:..||....:|||||.||| |
  Fly  1352 EELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLS----GVSELHKHGIVHRDIKTANIFL 1412

  Fly   169 LNTEGYAKLADFGVAGQL---TDTMAKRNTVIGTPFWMAPEVIEEI---GYDCVADIWSLGITAL 227
            ::.....||.|||.|.::   |....:....:||..:|||||..:.   |:...|||||:|...:
  Fly  1413 VDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVV 1477

  Fly   228 EMAEGKPPYGEIHP-MRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHE 291
            |||.||.|:.:... .:.:|.:.....|  :.|:..|.|..||:..||..:|..|.||.|||||.
  Fly  1478 EMASGKRPWAQFDSNFQIMFKVGMGEKP--QAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHN 1540

  Fly   292 FIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQA 331
            |.:..:         :|..:.:.|.:...||...:|.|.:
  Fly  1541 FCKYGR---------DECSSEQLQMQVRGSFRRNVATSSS 1571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	87/260 (33%)
		S_TKc	42..293	CDD:214567	87/260 (33%)
		Mst1_SARAH	608..655	CDD:288481
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	87/260 (33%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	87/259 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910