DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and MAP3K4

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_005913.3	Gene:	MAP3K4 / 4216	HGNCID:	6856	Length:	1608	Species:	Homo sapiens

Alignment Length:	313	Identity:	102/313 - (32%)
Similarity:	156/313 - (49%)	Gaps:	42/313 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ISSSCSFFKLKKLSE-------ESLLQPPEKVFDIMY--------------KLGEGSYGSVYKAV 60
            |..|...|:.|:..|       ..:...|:...::|:              |:|||.||.||..:
Human  1297 IQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCI 1361

  Fly    61 HKESSSIVAIKLVPVESDLHEIIK----EISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGS 121
            ..::..::|:|.:..:.:.|:.||    |:.|.:....|.:|||:|....:.:::|.||||..|:
Human  1362 SVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGT 1426

  Fly   122 VSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQL 186
            :.::.||   .|.|..|..........:..||....:|||||.|||.|.:.|..||.|||.:.:|
Human  1427 LEEVSRL---GLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKL 1488

  Fly   187 ---TDTM-AKRNTVIGTPFWMAPEVIEEI---GYDCVADIWSLGITALEMAEGKPPYGEI-HPMR 243
               ..|| .:.|:.:||..:||||||...   |:...|||||||...:||..||.|:.|. |..:
Human  1489 KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQ 1553

  Fly   244 AIFMI--PQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIR 294
            .::.:  ..|||    .|:|.|.|..||:|.||..:|..|.||::||:|.|::
Human  1554 IMYKVGMGHKPP----IPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVK 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	96/282 (34%)
		S_TKc	42..293	CDD:214567	95/278 (34%)
		Mst1_SARAH	608..655	CDD:288481
MAP3K4	NP_005913.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1190
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1274
		STKc_MEKK4	1342..1601	CDD:270796	94/265 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910