DRSC/TRiP Functional Genomics Resources

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Protein Alignment hpo and MAP3K1

DIOPT Version :9

Sequence 1:NP_001261092.1 Gene:hpo / 37247 FlyBaseID:FBgn0261456 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_005912.1 Gene:MAP3K1 / 4214 HGNCID:6848 Length:1512 Species:Homo sapiens


Alignment Length:273 Identity:86/273 - (31%)
Similarity:141/273 - (51%) Gaps:36/273 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 KLGEGSYGSVYKAVHKESSSIVAIKLVP----VESDLHEII----KEISIMQQCDSPYVVRYYGS 103
            ::|.|::.|.|:|....:.:::|:|.|.    ..|:..|::    :||.:|...:.|.::|..|:
Human  1248 QIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGA 1312

  Fly   104 YFKQ--YDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAAN 166
            ..::  |:|:|  |:...|||:.::. :.....|..:.......|:||.|||..:.||||:|.||
Human  1313 TCEKSNYNLFI--EWMAGGSVAHLLS-KYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGAN 1374

  Fly   167 ILLNTEGY-AKLADFGVAGQLTDTMAKRNT--------VIGTPFWMAPEVI--EEIGYDCVADIW 220
            :|:::.|. .::||||.|.:|    |.:.|        ::||..:|||||:  ::.|..|  |:|
Human  1375 LLIDSTGQRLRIADFGAAARL----ASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSC--DVW 1433

  Fly   221 SLGITALEMAEGKPPY-GEIHP--MRAIFMIPQ-KPPPSFREPDRWSTEFIDFVSKCLVKEPDDR 281
            |:|...:|||..|||: .|.|.  :..||.|.. ...||.  |...|....|...:||..:|.||
Human  1434 SVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSI--PSHLSPGLRDVALRCLELQPQDR 1496

  Fly   282 ATATELLEHEFIR 294
            ..:.|||:|...|
Human  1497 PPSRELLKHPVFR 1509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hpoNP_001261092.1 STKc_MST1_2 38..293 CDD:132943 85/270 (31%)
S_TKc 42..293 CDD:214567 85/270 (31%)
Mst1_SARAH 608..655 CDD:288481
MAP3K1NP_005912.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 67..181
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..304
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 416..436
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 511..532
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 602..624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 933..972
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1032..1087
STKc_MEKK1 1242..1509 CDD:270800 85/271 (31%)
S_TKc 1243..1508 CDD:214567 85/270 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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