DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and GckIII

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_650596.1	Gene:	GckIII / 42064	FlyBaseID:	FBgn0266465	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	198/591 - (33%)
Similarity:	287/591 - (48%)	Gaps:	108/591 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQCDSPYVVR 99
            ||.:|....::|:||:|.|:|.:...:..:||||::.:   |.::.:|.:||.::.|||||||.:
  Fly     9 PELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPYVTK 73

  Fly   100 YYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKA 164
            ||||:.|...|||.|||.|.||..|:|  :..:..|..|..||.:.|:||.|||..||:||||||
  Fly    74 YYGSFLKGTKLWIIMEYLGGGSALDLM--KAGSFEEMHIGIILREVLKGLDYLHSERKLHRDIKA 136

  Fly   165 ANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEM 229
            ||:||:.:|..||||||||||||:|.:||||.:|||||||||||::..||..||||||||||:|:
  Fly   137 ANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIEL 201

  Fly   230 AEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIR 294
            |:|:||..|:||||.:|:||:..||..  ...::..|.|||..||.|:|::|.||.|||::.||:
  Fly   202 AKGEPPNSELHPMRVLFLIPKNNPPQL--TGSYTKSFKDFVEACLNKDPENRPTAKELLKYPFIK 264

  Fly   295 NAKHRSILKPMLE-------------ETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHIT 346
            .||..:.|..:::             ||.:......::...||   :||.:.......|:  ||.
  Fly   265 KAKKNAYLIDLIDRFKKWKVSKGDESETESENSDSDSDAKQGG---SSQDEPWIMTVKGL--HIN 324

  Fly   347 D------NAFMEDPGTLVPEKF----------GEYQQSSASDA--------------TMIAHAEQ 381
            .      |:|......|..:|.          |..|.|.|::|              ..:..|.:
  Fly   325 SAPRAGVNSFQLQEHELTMQKLMQTTHSPAGGGGVQASPAANALSSSVSAVAASASSVSVITANE 389

  Fly   382 GVDEGTLGP----------------GGLRNLSKAAAPAAASSAASPLDMPAVDSGTMVELESNLG 430
            ||...:..|                ..:||||...|.....:||.|   |:
  Fly   390 GVSSASALPPQNSHVHNHNHNNINNNNIRNLSNKHATTTMLNAAPP---PS-------------- 437

  Fly   431 TMVINSDSDDSTTAKNNDDQKPRNRYRPQF--LEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQ 493
              .:.|.|..|...:.....||..|.....  |:..:.:.|..|...:..:.|   |:.||||||
  Fly   438 --SVTSSSSASELQQKRSSSKPELRQSRSAAPLDQVEDRRASLGLPLQSSVPT---PSTAEQQQQ 497

  Fly   494 QQQQQQQ--QQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQ 556
            ::..|::  ...:...:||.::..||..|...:.....|.:...|..|.           |:...
  Fly   498 RRSSQRESFHANNAALVASCSSSSNNHSHEEHVATNHASHVKHSGAGQR-----------LVQTN 551

  Fly   557 LIALNN 562
            ...|||
  Fly   552 SACLNN 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	132/257 (51%)
		S_TKc	42..293	CDD:214567	130/253 (51%)
		Mst1_SARAH	608..655	CDD:288481
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	135/274 (49%)
GckIII	NP_650596.1	S_TKc	13..263	CDD:214567	130/253 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438547
Domainoid	1	1.000	259	1.000	Domainoid score	I315
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D52072at50557
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	1	1.000	-	-		otm46741
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850