DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and Pak3

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	288	Identity:	99/288 - (34%)
Similarity:	163/288 - (56%)	Gaps:	14/288 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVES----DLHEIIKEISIMQQCDSPYVV 98
            |.:.:....::|:|:.|.|:.|...::.|.||:|.:.:::    ||  |:.||.:::..:...:|
  Fly   289 PRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDL--ILTEIRVLKDFNHKNLV 351

  Fly    99 RYYGSYFKQYD--LWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRD 161
            .:..:|..:.:  ||:.|||...|.::|:  :.:..:.|.:||.:..:||..:.:||.:..||||
  Fly   352 NFLDAYLLEPEDQLWVVMEYMDGGPLTDV--VTETVMKERQIACVCRETLYAISFLHAKGIIHRD 414

  Fly   162 IKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITA 226
            ||:.|:||..:|..|:.|||....: :...||.|::|||:||||||:....|....||||:||.|
  Fly   415 IKSDNVLLGMDGSVKVTDFGFCANI-EGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMA 478

  Fly   227 LEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHE 291
            :||.||:|||....|:||:::|.....|..:..|:.|....||:.:||..|.|.||||.|||.|.
  Fly   479 IEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHP 543

  Fly   292 FIRNAKHRSILKPMLEETCAIREQQRAN 319
            |:.:......|.|.::   |.::..|.|
  Fly   544 FLNDCSEVKALVPNIK---AAKKVLRRN 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	93/260 (36%)
		S_TKc	42..293	CDD:214567	92/256 (36%)
		Mst1_SARAH	608..655	CDD:288481
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	93/260 (36%)
		S_TKc	293..545	CDD:214567	92/256 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010