DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and stk24b

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_005165890.1	Gene:	stk24b / 406786	ZFINID:	ZDB-GENE-040426-2841	Length:	432	Species:	Danio rerio

Alignment Length:	390	Identity:	163/390 - (41%)
Similarity:	236/390 - (60%)	Gaps:	27/390 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQCD 93
            ::|...||::|..:.::|:||:|.|:|.:...:..:||||::.:   |.::.:|.:||:::.|||
Zfish    14 QNLKADPEELFTKLERIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

  Fly    94 SPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKI 158
            ||:|.:|||||.|...|||.|||.|.||..|:  |...:|.|.:|||||.:.|:||.|||..:||
Zfish    79 SPFVTKYYGSYLKDTKLWIIMEYLGGGSALDL--LEPGSLDETQIATILREILKGLEYLHSEKKI 141

  Fly   159 HRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLG 223
            ||||||||:||:.:|..||||||||||||||..||||.:|||||||||||::..||..|||||||
Zfish   142 HRDIKAANVLLSEQGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLG 206

  Fly   224 ITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELL 288
            |||:|:|:|:||:.::|||:.:|:||:..||:..  ..:.....:||..||.|||..|.||.|||
Zfish   207 ITAIELAKGEPPHSDLHPMKVLFLIPKNNPPTLE--GNYCKPLKEFVEACLNKEPSFRPTAKELL 269

  Fly   289 EHEFI-RNAKHRSILKPMLEETCAIR-EQQRANRSFGGVLAASQAKSLATQENGMQQHI-----T 346
            :|:.| |.||..|.|..::::....: ||.||..|.....:....::....:.|....|     .
Zfish   270 KHKLIVRFAKKTSYLTELIDKYKRWKAEQSRAESSSDESDSEPDGQASGGNDFGNDDWIFTIREK 334

  Fly   347 DNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASP 411
            |...:::..:||.|:....:..|.|.:|:|...             |..|.:.|..|||::...|
Zfish   335 DPKKLQNGASLVGEEEPNKRPLSQSLSTVITPV-------------LTELKEGAGEAAAATTVKP 386

Fly 412 411
Zfish 387 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	134/257 (52%)
		S_TKc	42..293	CDD:214567	132/253 (52%)
		Mst1_SARAH	608..655	CDD:288481
stk24b	XP_005165890.1	STKc_MST3_like	22..295	CDD:270786	138/276 (50%)
stk24b	XP_005165890.1	S_TKc	24..274	CDD:214567	132/253 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D967913at2759
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920