DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and stk25b

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_005171260.1	Gene:	stk25b / 406600	ZFINID:	ZDB-GENE-040426-2537	Length:	430	Species:	Danio rerio

Alignment Length:	472	Identity:	172/472 - (36%)
Similarity:	243/472 - (51%)	Gaps:	113/472 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEIS 87
            |:.:..::....||:.|....::|:||:|.|||.::..:..:||||::.:   |.::.:|.:||:
Zfish     4 LRDMQNQNSRLDPEEYFTKQERIGKGSFGEVYKGINNRTKEVVAIKIIDLEEAEDEIEDIQQEIT 68

  Fly    88 IMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYL 152
            ::.|||||||.:|||||.|...|||.|||.|.||..|:  |:...|.|..|||||.:.|:||.||
Zfish    69 VLSQCDSPYVTKYYGSYLKGTKLWIIMEYLGGGSALDL--LKPGPLEETYIATILREILKGLEYL 131

  Fly   153 HLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVA 217
            |..|||||||||||:||:.:|..||||||||||||||..||||.:|||||||||||::..||..|
Zfish   132 HSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196

  Fly   218 DIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRA 282
            |||||||||:|:|:|:||..::||||.:|:||:..||:..  ..:|..|.:||..||.|:|..|.
Zfish   197 DIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNTPPTLE--GSYSKPFKEFVEACLNKDPRFRP 259

  Fly   283 TATELLEHEFI-RNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHIT 346
            ||.|||:|:|| |..|..|.|..:::.....:.:
Zfish   260 TAKELLKHKFITRYTKKTSYLTELIDRYRRWKSE------------------------------- 293

  Fly   347 DNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASP 411
                            |...:||:.|:.|.                               |..|
Zfish   294 ----------------GHGDESSSDDSDMY-------------------------------AVHP 311

  Fly   412 LD-------------MPAVDSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNR-----YRP 458
            ||             .|.|...:|.:|:..    ..|:||:.:.|.|    ::|:::     ..|
Zfish   312 LDGDGDDRDHCPVWTFPTVRPSSMNKLQKG----YTNTDSEAAETVK----RQPKSQCLSALVSP 368

  Fly   459 QFLEHFDRKNA-GDGRG 474
            .|.|..:::.| |.|.|
Zfish   369 IFRELKEKRRACGGGMG 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	139/257 (54%)
		S_TKc	42..293	CDD:214567	137/253 (54%)
		Mst1_SARAH	608..655	CDD:288481
stk25b	XP_005171260.1	STKc_MST3_like	20..291	CDD:270786	143/274 (52%)
stk25b	XP_005171260.1	S_TKc	20..270	CDD:214567	137/253 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D967913at2759
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920