DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and myo3a

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_991142.2	Gene:	myo3a / 402814	ZFINID:	ZDB-GENE-041026-4	Length:	1775	Species:	Danio rerio

Alignment Length:	370	Identity:	138/370 - (37%)
Similarity:	210/370 - (56%)	Gaps:	39/370 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLV-PVESDLHEIIKEISIMQQ-CDSPYVVRY 100
            |...::|:..:|:|:||.|||..:|...|..|:|:: |:.....||..|.:|::. .|.|.||::
Zfish    17 PSDTWEIIETIGKGTYGKVYKVHNKVDGSKAAVKILDPIHDIDEEIEAEYNILKALSDHPNVVKF 81

  Fly   101 YGSYFKQ-----YDLWICMEYCGAGSVSDI---MRLRKKTLTEDEIATILSDTLQGLVYLHLRRK 157
            :|.::|:     ..||:.:|.|..|||:|:   |..|...:.|..||.||.:.|.||.:||:.:.
Zfish    82 FGMFYKKDVKTGDQLWLVLELCNGGSVTDLAKGMLKRGDRMEEPIIAFILHEALMGLQHLHVNKT 146

  Fly   158 IHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIE-----EIGYDCVA 217
            ||||:|..||||.|:|..||.||||:.|||:|..:|||.:|||||||||||.     :..||...
Zfish   147 IHRDVKGNNILLTTDGGIKLVDFGVSAQLTNTRLRRNTSVGTPFWMAPEVIACEQQLDSTYDERC 211

  Fly   218 DIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRA 282
            |:|||||||:|:.:|.||..|:|||||:|.||:.|||:..:|:.||.:|.||:.|||:|:.:.|.
Zfish   212 DVWSLGITAIELGDGDPPLAELHPMRALFKIPRNPPPTLHQPELWSNDFNDFIRKCLIKDFELRP 276

  Fly   283 TATELLEHEFIRNAKHR-SILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQ--- 343
            ...:||:|.||:....| ..|:..|.|...:.:|.       |::..:.....:.:::..:.
Zfish   277 NVLDLLQHVFIKQIVGREKTLQKQLMELIDLNQQM-------GIIEKTSLLGKSDRDSDSRHERI 334

  Fly   344 HITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTL 388
            |...|::|:.            |..:..||..:|..|. :||.|:
Zfish   335 HTKKNSYMKS------------QSQTCDDADDLATLEV-LDENTI 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	119/269 (44%)
		S_TKc	42..293	CDD:214567	118/265 (45%)
		Mst1_SARAH	608..655	CDD:288481
myo3a	NP_991142.2	PKc_like	2..287	CDD:328722	119/269 (44%)
myo3a	NP_991142.2	MYSc_Myo3	364..1091	CDD:276830	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910