DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Myo3b

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001380706.1	Gene:	Myo3b / 366069	RGDID:	1560313	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	135/340 - (39%)
Similarity:	205/340 - (60%)	Gaps:	29/340 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIK-EISIMQQCDS- 94
            |||..|.: .::|...:|:|:||.|||..::...|:.|:|::...:|:.|.:: |.:|:|...|
  Rat    34 ESLPDPMD-TWEIRETIGKGTYGKVYKVANRRDGSLAAVKILDSVNDVDEEVEAEYNILQFLPSH 97

  Fly    95 PYVVRYYGSYFKQ-----YDLWICMEYCGAGSVSDIMR--LR-KKTLTEDEIATILSDTLQGLVY 151
            |.||::||.::|.     ..||:.:|.|..|||:::::  || .|.|.|..|:.||..:|.||.:
  Rat    98 PNVVKFYGMFYKADRCVGGQLWLVLELCNGGSVTELVKGLLRCGKRLDEALISYILYGSLLGLQH 162

  Fly   152 LHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIE-----EI 211
            ||..|.||||:|..||||.|||..||.||||:.|||.|..:|||.:|||||||||||.     :.
  Rat   163 LHHHRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDS 227

  Fly   212 GYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVK 276
            .||...|:|||||||:|:.:|.||..|:||::.:|.||:.|||:...||.|..||..|:|:||:|
  Rat   228 SYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFKIPRNPPPTLLHPDNWCEEFNHFISQCLIK 292

  Fly   277 EPDDRATATELLEHEFIRNAKHRSI-LKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENG 340
            :.:.|.:.|.||:|.||:..:.:.: |:..|.:  .:.:|:..|     .:|.::.:.:.|   |
  Rat   293 DFEKRPSVTHLLDHPFIKGTQGKVLFLQKQLAK--VLWDQKHQN-----PVAKTRHERMHT---G 347

  Fly   341 MQQHITD--NAFMED 353
            ...|:.|  ...:||
  Rat   348 RPHHVEDAGKCCLED 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	118/269 (44%)
		S_TKc	42..293	CDD:214567	118/265 (45%)
		Mst1_SARAH	608..655	CDD:288481
Myo3b	NP_001380706.1	MYSc_Myo3	373..1062	CDD:276830
		IQ	1102..1124	CDD:197470
		PKc_like	20..310	CDD:419665	123/276 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910