DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Stk24

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_038949467.1	Gene:	Stk24 / 361092	RGDID:	1561742	Length:	443	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	177/446 - (39%)
Similarity:	247/446 - (55%)	Gaps:	70/446 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VDMKSPNISSSCSFFKLKKL---SEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIK 71
            ::.|.|.:..:....|...|   .:|:|...||::|..:.|:|:||:|.|:|.:...:..:||||
  Rat     1 MESKVPRLGLALKRRKATPLHPGGKETLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIK 65

  Fly    72 LVPV---ESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTL 133
            ::.:   |.::.:|.:||:::.|||||||.:|||||.|...|||.|||.|.||..|:  |....|
  Rat    66 IIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL--LEPGPL 128

  Fly   134 TEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIG 198
            .|.:|||||.:.|:||.|||..:||||||||||:||:..|..||||||||||||||..||||.:|
  Rat   129 DEIQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVG 193

  Fly   199 TPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWS 263
            ||||||||||::..||..||||||||||:|:|:|:||:.|:|||:.:|:||:..||:..  ..:|
  Rat   194 TPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLE--GSYS 256

  Fly   264 TEFIDFVSKCLVKEPDDRATATELLEHEF-IRNAKHRSILKPML-----------------EETC 310
            ....:||..||.|||..|.||.|||:|:| |||||..|.|..::                 |::.
  Rat   257 RPLKEFVEACLNKEPSFRPTAKELLKHKFIIRNAKKTSYLTELIDRYKRWKAEQSHEDSSSEDSD 321

  Fly   311 AIREQQRANRSFGG----VLAASQAKSLATQENGMQQ--HITDNAFMEDP--------GTLVPEK 361
            ...:.|.:..|..|    .:.....|:|   |||..|  .:..|...:.|        .|::...
  Rat   322 VETDSQASGGSDSGDWIFTIREKDPKNL---ENGTLQPSDLERNKMKDFPKRPFSQCLSTIISPL 383

  Fly   362 FGEYQQSS-------------------ASDA------TMIAHAEQGVDEGTLGPGG 392
            |.|.::.|                   |.:|      ||:|...|.:...:|..||
  Rat   384 FAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGG 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	139/258 (54%)
		S_TKc	42..293	CDD:214567	137/254 (54%)
		Mst1_SARAH	608..655	CDD:288481
Stk24	XP_038949467.1	STKc_MST3_like	34..307	CDD:270786	144/276 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D967913at2759
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920