DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and max-2

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001300485.1	Gene:	max-2 / 3565400	WormBaseID:	WBGene00003144	Length:	649	Species:	Caenorhabditis elegans

Alignment Length:	301	Identity:	114/301 - (37%)
Similarity:	181/301 - (60%)	Gaps:	18/301 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KKLSEESLLQPPEKV---------FDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHE- 81
            :|||:..:|....::         :::..::|.|:.|:|:.|....|:.:||:|.:..::...:
Worm   355 EKLSDSEVLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKE 419

  Fly    82 -IIKEISIMQQCDSPYVVRYYGSYFKQY-DLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSD 144
             ::.||.:|:|...|.:|.|..||.... |||:.|:|...|:::|:  :.|..|.|.:||.:|.:
Worm   420 MLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDV--VVKTELDEGQIAAVLQE 482

  Fly   145 TLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIE 209
            .|:.|.:||....:|||||:.|:||...|..||.|.|...|: ...:||:||:|||:||:||::.
Worm   483 CLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI-QPGSKRDTVVGTPYWMSPEILN 546

  Fly   210 EIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCL 274
            :..|:...|||||||.||||.:|:|||....|::||::|.|...|..::.||.|:||.:|:.|||
Worm   547 KKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCL 611

  Fly   275 VKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQ 315
            |.:||.||..||||.|.|::.||..|.|.|.:.   |:||:
Worm   612 VVDPDQRADTTELLAHPFLKKAKPLSSLIPYIR---AVREK 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	101/266 (38%)
		S_TKc	42..293	CDD:214567	101/253 (40%)
		Mst1_SARAH	608..655	CDD:288481
max-2	NP_001300485.1	STKc_PAK	378..631	CDD:270789	102/255 (40%)
max-2	NP_001300485.1	S_TKc	379..630	CDD:214567	101/253 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910