Protein Alignment hpo and Taok3

DIOPT Version :9

• Sequence 1: NP_001261092.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001074777.1
• Gene: Taok3 / 330177
• MGIID: 3041177
• Length: 898
• Species: Mus musculus
• Alignment Length: 780
• Identity: 207/780 - (26%)
• Similarity: 320/780 - (41%)
• Gaps: 202/780 - (25%)

  Fly    12 MKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE 76
            :|.|.|:.  .|||          ..||::|..::::|.||:|:||.|.:..::.:||:|.:...
Mouse     6 LKDPEIAD--LFFK----------DDPEELFIDLHEIGHGSFGAVYFATNAHTNEVVAVKKMSYS 58

  Fly    77 -SDLHE----IIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTED 136
             ...||    |:||:..:||...|..:.|.|.|.|::..|:.|||| .||.||::.:.||.|.|.
Mouse    59 GKQTHEKWQDILKEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYC-LGSASDLLEVHKKPLQEV 122

  Fly   137 EIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPF 201
            |||.|....||||.|||....|||||||.||||...|..||||||.|...:..    |:.:|||:
Mouse   123 EIAAITHGALQGLAYLHFHSLIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPY 183

  Fly   202 WMAPEVI---EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWS 263
            |||||||   :|..||...||||||||.:|:||.|||...::.|.|::.|.|...|:.:..: |:
Mouse   184 WMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSRE-WT 247

  Fly   264 TEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEET-CAIREQQRANRSFGGVLA 327
            ..|..||..||.|.|.:|..|.|||.|:|||..:...:|..:::.| .|:||...        |.
Mouse   248 DSFRRFVDYCLHKIPQERPAAVELLRHDFIRRERPPKVLIDLIQRTKDAVRELDN--------LQ 304

  Fly   328 ASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGG 392
            ..:.|.:..||       |.|..:.:            .|....|....::..:.||    ..|.
Mouse   305 YRKMKKILFQE-------TRNGPLNE------------SQEEEEDGEQGSNLNREVD----SLGS 346

  Fly   393 LRNL--SKAAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNR 455
            :.::  :..:..:.:||..|..::....|..:|.::.:.||    ::|..||..|.
Mouse   347 IHSIPSTSVSTGSRSSSVNSMQEVMDESSSELVMMQEDEGT----ANSSASTVHKK--------- 398

  Fly   456 YRPQFLEH-FDRKNAGDG--RGDEKP----------------IATEYSPAAAEQQQQQQQQQQQ- 500
                  :| |.|..||.|  |.:.:|                .||..|.:...:|..:.:|:.:
Mouse   399 ------DHVFVRDEAGHGDPRPEPRPTQSVQSRALHYRNRERFATIKSASLVTRQIHEHEQENEL 457

  Fly   501 ----------QQQDEQHLASGANDLNNW--EHNMEMQFQ------------------QISAINQ- 534
                      ::|.::.|.:..|.|...  ||.:::|.:                  |::.|.:
Mouse   458 REQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVATIEKE 522

  Fly   535 ---YGLQQHQQQQQVL---------------MAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPA 581
               ....:.:.|||:|               ..|.:..|::....|:.:   |......|:.|..
Mouse   523 AKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDH---STPKKEKQERISK 584

  Fly   582 -AAPAQPPPAYQNQHMHTQSHAYVE---------------------------------------- 605
             ....|...|.:..|:.||...|.:
Mouse   585 HKENLQHTQAEEEAHLLTQQRLYYDRNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAML 649

  Fly   606 -------GEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQNIN 663
                   .|.|:.:..|...|...|..:.|:.||| .||  :||.:|:..:...:....|||..|
Mouse   650 IRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELE-NQL--EYNKRRERELHRKHVMELRQQPKN 711

  Fly   664  663
            Mouse   712  711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	115/262 (44%)
		S_TKc	42..293	CDD:214567	113/258 (44%)
		Mst1_SARAH	608..655	CDD:288481	13/46 (28%)
Taok3	NP_001074777.1	PKc_like	2..314	CDD:389743	131/333 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..375		10/74 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..424		5/18 (28%)
		PTZ00121	<415..881	CDD:173412	49/303 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..596		6/33 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910