DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and hep

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001368982.1	Gene:	hep / 32256	FlyBaseID:	FBgn0010303	Length:	1294	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	178/756 - (23%)
Similarity:	280/756 - (37%)	Gaps:	215/756 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SEPEVTSVVDMKSPNISSSCSFFKLKKLSEE------SLLQPPEKVFDIMY--KLGEGSYGSVYK 58
            :.|.:..:.....|.:|.  :..|||.:.|:      :..|.|..:.|:.:  .||.|:.|:|.|
  Fly   151 TRPVILPLPTPPHPPVSE--TDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVK 213

  Fly    59 AVHKESSSIVAIKLVPVESDLHE---IIKEIS-IMQQCDSPYVVRYYGSYFKQYDLWICMEYCGA 119
            .:|..|::|:|:|.:....:..|   |:.::. :::..|..|:|:..|.:.:..|:|||||....
  Fly   214 MMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSM 278

  Fly   120 GSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRR-KIHRDIKAANILLNTEGYAKLADFGVA 183
             ....:::|.||.:.|..:..:...|:..|.||..:. .||||:|.:|||::..|..||.|||::
  Fly   279 -CFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGIS 342

  Fly   184 GQLTDTMAKRNTVIGTPFWMAPEVIE--EIGYDCVADIWSLGITALEMAEGKPPY-GEIHPMRAI 245
            |:|.|:.|...:. |...:||||.|:  :..||..||:||||||.:|:|..:.|| |.......:
  Fly   343 GRLVDSKANTRSA-GCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVL 406

  Fly   246 FMIPQKPPP--SFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEE 308
            ..:....||  .:.|...:|.:|.|||.|||.|...||....|||...|||..:...:..|...:
  Fly   407 TKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQ 471

  Fly   309 TCAIREQQ-RAN---------------------------RSFGGVLAASQAKSLATQENGMQQHI 345
              :|::.: |||                           .|.||.:...:|.:.|.|.....|.
  Fly   472 --SIKDNRLRANGDPTLQRATATGSAIGSGAGSLAGSGSGSAGGAVKYGRATTYAGQSPTNPQK- 533

  Fly   346 TDNAFMEDPGTLVPEKFGEYQQSSA----SDATMIAHAEQGVDEGTL--------------GPGG 392
                      |:.|.:...|||..:    ..||.:..........|.              |.||
  Fly   534 ----------TIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTPTATTNCFGGSGNGNGRGNGSGG 588

  Fly   393 LRNLSKAAAPAAASSAASPLDMPAVDSGTMVEL-----------------------------ES- 427
            ..|.|      .:||:||||..|:...|.:..|                             ||
  Fly   589 SGNGS------GSSSSASPLSPPSAGIGDLNRLYRKSPFMQRKLSNGSHHPHYKYNDESPKKESM 647

  Fly   428 ----------NLGTMVINSDSDDSTTA-----KNND----------------------------- 448
                      ||.|...:....:||..     .||.
  Fly   648 FSSIGQSILRNLTTSPFSQKKHNSTATTIPLPHNNQTLITDAATAAAAAATATTPPNIAATVLTT 712

  Fly   449 --DQKPRNRYRPQFLEHFDRKNAGD---------GRGDEKP------IATEYSPAAAEQQQQQQQ 496
              ...|..|...:..:.:|..::..         |.....|      ..|| ||......|||||
  Fly   713 TPTTTPTWRLPTENSQAYDSCDSSSNATTTTLNLGLSSPSPSLPRKQFPTE-SPTLQLTSQQQQQ 776

  Fly   497 QQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALN 561
            .|:.|..::..:.     |..:.| .:.|.::..|..:|     |||:|
  Fly   777 PQRLQPGNQSPIV-----LQRFYH-QQNQLREKEAAERY-----QQQRQ---------------- 814

  Fly   562 NQPNLLLSNAAPMGQQGIPAAAPAQPPPAYQ--NQHMHTQS 600
             ||.:.:::..|.....:|      |||:..  :....|||
  Fly   815 -QPPVGVTSTNPFHSNYVP------PPPSTHSTSSQSSTQS 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	89/266 (33%)
		S_TKc	42..293	CDD:214567	88/262 (34%)
		Mst1_SARAH	608..655	CDD:288481
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	95/298 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910