DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and Oxsr1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001101664.1	Gene:	Oxsr1 / 316064	RGDID:	1310466	Length:	527	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	165/562 - (29%)
Similarity:	253/562 - (45%)	Gaps:	97/562 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LSEESLLQP---PEKVFDIMYKLGEGSYGSV---YKAVHKESSSIVAIKLVPVESDLHEIIKEIS 87
            :||:|...|   ....:::...:|.|:...|   |.|..||..:|..|.|...::.:.|::|||.
  Rat     1 MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKERVAIKRINLEKCQTSMDELLKEIQ 65

  Fly    88 IMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMR-------LRKKTLTEDEIATILSDT 145
            .|.||..|.:|.||.|:..:.:||:.|:....|||.||::       .:...|.|..|||||.:.
  Rat    66 AMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKGGVLDESTIATILREV 130

  Fly   146 LQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVA------GQLTDTMAKRNTVIGTPFWMA 204
            |:||.|||...:||||:||.||||..:|..::|||||:      |.:|.... |.|.:|||.|||
  Rat   131 LEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMA 194

  Fly   205 PEVIEEI-GYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSF------REP-DR 261
            |||:|:: |||..|||||.||||:|:|.|..||.:..||:.:.:..|..|||.      :|. .:
  Rat   195 PEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLDTGVQDKEMLKK 259

  Fly   262 WSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSIL-KPMLEETCAIREQQRANRSFGGV 325
            :...|...:|.||.|:|:.|.||.|||.|:|.:.||::..| :.:|:....|.|:.:..|...|
  Rat   260 YGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKILQRAPTISERSKKVRRVPG- 323

  Fly   326 LAASQAKSLATQENGMQQHITDNAFMEDP-----------GTLVPEKFGEYQQSSASD--ATMI- 376
               |..:...|::.|.:.  :|:.|.|:.           ...|.:.....:..||:|  .|::
  Rat   324 ---SSGRLHKTEDGGWEW--SDDEFDEESEEGKAAISQLRSPRVKDSLSNSELFSAADPMGTLLQ 383

  Fly   377 ------AHAEQGVDEGTLGPGGLRNLSKA--AAPAAASSAASPLDMPAVDSGTMVELESNLGTMV 433
                  ||..|...:....|..:..|..|  |.||.|.|:........|....::.|.::
  Rat   384 VPEQISAHLPQPASQMPTQPAQVSLLPPAEPAKPAQARSSGERSQETKVPISLVLRLRNS----- 443

  Fly   434 INSDSDDSTTAKNNDDQKPRNRYRPQFLEHFDRKNAGDGRGDEKPIATEYSPA----------AA 488
                            :|..|..|.:|.         .||...:.::.|...|          .|
  Rat   444 ----------------KKELNDIRFEFT---------PGRDTAEGVSQELISAGLVDGRDLVIVA 483

  Fly   489 EQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQIS 530
            ...|:..::.|..:.....||||....:..:....:.|.|:|
  Rat   484 ANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	110/278 (40%)
		S_TKc	42..293	CDD:214567	110/274 (40%)
		Mst1_SARAH	608..655	CDD:288481
Oxsr1	NP_001101664.1	STKc_OSR1_SPAK	15..291	CDD:270787	110/276 (40%)
Oxsr1	NP_001101664.1	S_TKc	17..291	CDD:214567	110/274 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910