Protein Alignment hpo and Stk4

DIOPT Version :10

• Sequence 1: NP_611427.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001101270.1
• Gene: Stk4 / 311622
• RGDID: 1312035
• Length: 487
• Species: Rattus norvegicus
• Alignment Length: 644
• Identity: 291/644 - (45%)
• Similarity: 374/644 - (58%)
• Gaps: 177/644 - (27%)

  Fly    25 KLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIM 89
            :||||.|:||.:.||:|||::.|||||||||||||:|||:..|||||.|||||||.|||||||||
  Rat    13 QLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIM 77

  Fly    90 QQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHL 154
            ||||||:||:|||||||..||||.||||||||||||:|||.||||||||||||..||:||.|||.
  Rat    78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 142

  Fly   155 RRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADI 219
            .|||||||||.||||||||:||||||||||||||||||||||||||||||||||:||||:|||||
  Rat   143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 207

  Fly   220 WSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATA 284
            |||||||:|||||||||.:|||||||||||..|||:||:|:.||..|:|||.:||||.|:.||||
  Rat   208 WSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEVWSDNFMDFVKQCLVKSPEQRATA 272

  Fly   285 TELLEHEFIRNAKHRSILKPMLEETCAIR-EQQRANRSFGGVLAASQAKSLATQENGMQQHITDN 348
            |:||:|.|:::||..:||:.::.|...:: ::|.|                  |:..:.|...:|
  Rat   273 TQLLQHPFVKSAKGAAILRDLINEAMDVKLKRQEA------------------QQRAVDQDDDEN 319

  Fly   349 AFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPLD 413
            :                ::......||:..|  |.|.||:              ..||:.:.
  Rat   320 S----------------EEDEMDSGTMVRAA--GDDMGTV--------------RVASTMSG--- 349

  Fly   414 MPAVDSGTMVE----LESNLGTMVINS-DSDDSTTAKNNDD-QKPRNRYRPQFLEHFDRKNAGDG 472
                .:.||:|    |.|.|||||||: |.::..|.|..|: .:|.   :|.|||:|
  Rat   350 ----GANTMIEHGDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPA---KPSFLEYF-------- 399

  Fly   473 RGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGL 537
                                :|::::.|.....::::....:.::|:
  Rat   400 --------------------EQKEKENQINSFGKNVSGSLKNSSDWK------------------ 426

  Fly   538 QQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHA 602
                                                     ||.
  Rat   427 -----------------------------------------IPQ--------------------- 429

  Fly   603 YVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQN 661
              :|::||||..|.:||.:||..:|..||.|:|::.:||.:|||||:||:.||::||||
  Rat   430 --DGDYEFLKSWTVEDLQKRLSALDPMMEQEMEEIRQKYRSKRQPILDAIEAKKRRQQN 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_611427.1	STKc_MST1_2	38..293	CDD:132943	207/254 (81%)
		SARAH_Hpo	606..661	CDD:439183	28/54 (52%)
Stk4	NP_001101270.1	STKc_MST1_2	26..281	CDD:132943	207/254 (81%)
		SARAH_MST1	432..480	CDD:439181	23/47 (49%)