DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and Stk4

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001101270.1	Gene:	Stk4 / 311622	RGDID:	1312035	Length:	487	Species:	Rattus norvegicus

Alignment Length:	644	Identity:	291/644 - (45%)
Similarity:	374/644 - (58%)	Gaps:	177/644 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIM 89
            :||||.|:||.:.||:|||::.|||||||||||||:|||:..|||||.|||||||.|||||||||
  Rat    13 QLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIM 77

  Fly    90 QQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHL 154
            ||||||:||:|||||||..||||.||||||||||||:|||.||||||||||||..||:||.|||.
  Rat    78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 142

  Fly   155 RRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADI 219
            .|||||||||.||||||||:||||||||||||||||||||||||||||||||||:||||:|||||
  Rat   143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 207

  Fly   220 WSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATA 284
            |||||||:|||||||||.:|||||||||||..|||:||:|:.||..|:|||.:||||.|:.||||
  Rat   208 WSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEVWSDNFMDFVKQCLVKSPEQRATA 272

  Fly   285 TELLEHEFIRNAKHRSILKPMLEETCAIR-EQQRANRSFGGVLAASQAKSLATQENGMQQHITDN 348
            |:||:|.|:::||..:||:.::.|...:: ::|.|                  |:..:.|...:|
  Rat   273 TQLLQHPFVKSAKGAAILRDLINEAMDVKLKRQEA------------------QQRAVDQDDDEN 319

  Fly   349 AFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPLD 413
            :                ::......||:..|  |.|.||:              ..||:.:.
  Rat   320 S----------------EEDEMDSGTMVRAA--GDDMGTV--------------RVASTMSG--- 349

  Fly   414 MPAVDSGTMVE----LESNLGTMVINS-DSDDSTTAKNNDD-QKPRNRYRPQFLEHFDRKNAGDG 472
                .:.||:|    |.|.|||||||: |.::..|.|..|: .:|.   :|.|||:|
  Rat   350 ----GANTMIEHGDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPA---KPSFLEYF-------- 399

  Fly   473 RGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGL 537
                                :|::::.|.....::::....:.::|:
  Rat   400 --------------------EQKEKENQINSFGKNVSGSLKNSSDWK------------------ 426

  Fly   538 QQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHA 602
                                                     ||.
  Rat   427 -----------------------------------------IPQ--------------------- 429

  Fly   603 YVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQN 661
              :|::||||..|.:||.:||..:|..||.|:|::.:||.:|||||:||:.||::||||
  Rat   430 --DGDYEFLKSWTVEDLQKRLSALDPMMEQEMEEIRQKYRSKRQPILDAIEAKKRRQQN 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	207/254 (81%)
		S_TKc	42..293	CDD:214567	204/250 (82%)
		Mst1_SARAH	608..655	CDD:288481	23/46 (50%)
Stk4	NP_001101270.1	STKc_MST1_2	26..281	CDD:132943	207/254 (81%)
Stk4	NP_001101270.1	Mst1_SARAH	433..480	CDD:402983	23/46 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	428	1.000	Domainoid score	I579
eggNOG	1	0.900	-	-		E1_KOG0574
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	553	1.000	Inparanoid score	I1083
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247842at33208
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	1	1.000	-	-		otm46401
orthoMCL	1	0.900	-	-		OOG6_102280
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1715
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830