DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and Pak6

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001099968.1	Gene:	Pak6 / 296078	RGDID:	1306213	Length:	681	Species:	Rattus norvegicus

Alignment Length:	281	Identity:	108/281 - (38%)
Similarity:	158/281 - (56%)	Gaps:	10/281 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHE--IIKEISIMQQCDSPYVVRY 100
            |..:.|...|:||||.|.|..|..|.|...||:|::.:......  :..|:.||:......||..
  Rat   403 PRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEM 467

  Fly   101 YGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAA 165
            |.||....:||:.||:...|:::||  :.:..|.|::|||:....||.|.|||.:..||||||:.
  Rat   468 YKSYLVGEELWVLMEFLQGGALTDI--ISQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSD 530

  Fly   166 NILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMA 230
            :|||..:|..||:|||...|::..:.||.:::|||:|||||||....|....|||||||..:||.
  Rat   531 SILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMV 595

  Fly   231 EGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRN 295
            :|:|||....|::|:..:...|||..:...:.|....||:.:.||:||.:||||.|||:|.|:..
  Rat   596 DGEPPYFSDSPVQAMKRLRDSPPPKLKNSYKVSPVLRDFLERMLVREPQERATAQELLDHPFLLQ 660

  Fly   296 AKHRSILKPMLE------ETC 310
            ......|.|:::      .||
  Rat   661 TGLPECLVPLIQLYRKQTSTC 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	103/256 (40%)
		S_TKc	42..293	CDD:214567	102/252 (40%)
		Mst1_SARAH	608..655	CDD:288481
Pak6	NP_001099968.1	PBD	11..67	CDD:395634
Pak6	NP_001099968.1	STKc_PAK6	385..681	CDD:270821	106/279 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910