Protein Alignment hpo and Map2k5

DIOPT Version :10

• Sequence 1: NP_611427.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_038936881.1
• Gene: Map2k5 / 29568
• RGDID: 61890
• Length: 487
• Species: Rattus norvegicus
• Alignment Length: 281
• Identity: 101/281 - (35%)
• Similarity: 158/281 - (56%)
• Gaps: 37/281 - (13%)

  Fly    14 SPNISSSCSFFKLKKLSEE--SLL---QPPEKVFDIMYK--LGEGSYGSVYKAVHKESSSIVAIK 71
            ||.:|.|.....|||.|.|  .:|   |..|:  ||.|:  ||.|:.|:||||.|..|..|:|:|
  Rat   133 SPVVSDSLPSNSLKKSSAELRKILANGQMNEQ--DIRYRDTLGHGNGGTVYKAYHVPSGKILAVK 195

  Fly    72 LVPVESDLH---EIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTL 133
            ::.::..|.   :|:.|:.|:.:|||.|::.:||::|.:..:.||.|:...||: |:.|    .:
  Rat   196 VILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSL-DVYR----KI 255

  Fly   134 TEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIG 198
            .|..:..|....::||.||...:.:|||:|.:|:|:||.|..||.||||:.||.:::||  |.:|
  Rat   256 PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAK--TYVG 318

  Fly   199 TPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPY-------GEIHPMRAIFMI-----PQK 251
            |..:||||.|....|...:|:|||||:.:|:|.|:.||       |.:.|::.:..|     |..
  Rat   319 TNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVL 383

  Fly   252 PPPSFREPDRWSTEFIDFVSK 272
            |...|.||      |:.|:::
  Rat   384 PLGEFSEP------FVHFITQ 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_611427.1	STKc_MST1_2	38..293	CDD:132943	90/252 (36%)
		SARAH_Hpo	606..661	CDD:439183
Map2k5	XP_038936881.1	PB1_Map2k5	17..107	CDD:99717
		Protein Kinases, catalytic domain	164..401	CDD:473864	89/250 (36%)