Protein Alignment hpo and Map4k2

DIOPT Version :9

• Sequence 1: NP_001261092.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_006230815.1
• Gene: Map4k2 / 293694
• RGDID: 1308199
• Length: 821
• Species: Rattus norvegicus
• Alignment Length: 586
• Identity: 176/586 - (30%)
• Similarity: 263/586 - (44%)
• Gaps: 102/586 - (17%)

  Fly    35 LQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE--SDLHEIIKEISIMQQCDSPYV 97
            ||.|...|:::.::|.|:||.||||....:|.:.|:|:|.::  .|:..:.:||:|:::|..|.|
  Rat     9 LQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNV 73

  Fly    98 VRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDI 162
            |.|.|||.:...||||||:||.||:.:|.. ....|.|.:||.:..:.|:||.:||.:.||||||
  Rat    74 VAYIGSYLRNDRLWICMEFCGGGSLQEIYH-ATGPLEERQIAYVCREALKGLHHLHSQGKIHRDI 137

  Fly   163 KAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---EEIGYDCVADIWSLGI 224
            |.||:||..:|..|||||||:|:||.::|||.:.||||:||||||.   .:.||:.:.|:|:|||
  Rat   138 KGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGI 202

  Fly   225 TALEMAEGKPPYGEIHPMRAIFMIPQK--PPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATEL 287
            ||:|:.|.:||...:|||||:.::.:.  .||..|:..||:..|..|:...|.|.|..|.||.:|
  Rat   203 TAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQTFHHFLKLALTKNPKKRPTAEKL 267

  Fly   288 LEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFME 352
            |:|.|.......::|..:|::.                                          .
  Rat   268 LQHPFTTQPLPPALLTQLLDKA------------------------------------------S 290

  Fly   353 DP--GTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLR-NLSKAAAPAAASSAASPLDM 414
            ||  |||.||. .|.:.......|:.:....|..|.|  |..:: :..|..||....:  .||..
  Rat   291 DPHLGTLSPED-SELETHDMFPDTIHSRGHHGPAERT--PSEIQFHQVKFGAPRRKET--DPLSE 350

  Fly   415 PAVDSGTMV---ELESNLGTMVINSDSDDSTTAK--------NNDDQKPRNRYRPQF--LEHFDR 466
            |..:..|.:   ||..:|...|..:..:.|.|.:        ::.|.......|..|  |.|.:
  Rat   351 PWEEEWTFLGKEELSRSLLQSVQEALEERSLTIRPAIELQELDSPDDAIGTIKRAPFMGLPHTE- 414

  Fly   467 KNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLN--------------- 516
            ..:.|......|......||...............:|.|.|..|..:.|.
  Rat   415 STSDDNAQSCSPGTLSAPPAGPSSPPLLPTAWATLKQREDHERSSCHGLPPTPKVHMGACFSKVF 479

  Fly   517 -----------NWEHNMEM-QFQQISAINQ-YGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLL 568
                       .|.|.:.. ||..:.|... |.|..|:..:..|  ..|::.:.|.|....|:||
  Rat   480 NGCPLQIHAAVTWVHPVTRDQFLVVGAEEGIYTLNLHELHEDTL--EKLISHRCIWLYCVNNVLL 542

  Fly   569 S 569
            |
  Rat   543 S 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	115/261 (44%)
		S_TKc	42..293	CDD:214567	114/257 (44%)
		Mst1_SARAH	608..655	CDD:288481
Map4k2	XP_006230815.1	STKc_MAP4K3_like	16..272	CDD:270788	114/256 (45%)
		S_TKc	16..272	CDD:214567	114/256 (45%)
		CNH	489..801	CDD:214481	16/57 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910