DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Pak4

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001099708.1	Gene:	Pak4 / 292756	RGDID:	1307705	Length:	593	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	103/289 - (35%)
Similarity:	159/289 - (55%)	Gaps:	20/289 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHE------IIKEISIMQQCDSPY 96
            |....|...|:||||.|.|..|..:.|..:||:|    :.||.:      :..|:.||:......
  Rat   319 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVK----KMDLRKQQRRELLFNEVVIMRDYRHEN 379

  Fly    97 VVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRD 161
            ||..|.||....:||:.||:...|:::||:...:  :.|::||.:....||.|..||.:..||||
  Rat   380 VVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHRD 442

  Fly   162 IKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITA 226
            ||:.:|||..:|..||:|||...|::..:.:|.:::|||:|||||:|..:.|....||||||:..
  Rat   443 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMV 507

  Fly   227 LEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHE 291
            :||.:|:|||....|::|:.||....||..:...:.|.....|:.:.||::|..||||.|||:|.
  Rat   508 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHP 572

  Fly   292 FIRNAKHRSILKPMLEETCAIREQQRANR 320
            |:..|...:.:.|::        :|..||
  Rat   573 FLTKAGPPASIVPLM--------RQHRNR 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	97/260 (37%)
		S_TKc	42..293	CDD:214567	96/256 (38%)
		Mst1_SARAH	608..655	CDD:288481
Pak4	NP_001099708.1	CRIB_PAK_like	10..48	CDD:238526
		PKc_like	302..593	CDD:304357	101/287 (35%)
		S_TKc	328..574	CDD:214567	95/251 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910