DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and pak2a

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001002717.1	Gene:	pak2a / 266749	ZFINID:	ZDB-GENE-021011-2	Length:	517	Species:	Danio rerio

Alignment Length:	304	Identity:	110/304 - (36%)
Similarity:	182/304 - (59%)	Gaps:	16/304 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KLSEESLLQ---------PPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHE-- 81
            |:::|.:::         .|:|.:....|:|:|:.|:||.|:...:...||||.:.::....:
Zfish   219 KMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVYTAIDVATGQEVAIKQINLQKQPKKEL 283

  Fly    82 IIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTL 146
            ||.||.:|::..:|.:|.:..|:....:|::.|||...||::|:  :.:..:.|.:||.:..:.|
Zfish   284 IINEILVMKELKNPNIVNFLDSFLVGDELFVVMEYLAGGSLTDV--VTETCMDEAQIAAVCRECL 346

  Fly   147 QGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEI 211
            |.|.:||..:.||||||:.|:||..:|..||.|||...|:|...:||:|::|||:||||||:...
Zfish   347 QALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRK 411

  Fly   212 GYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVK 276
            .|....|||||||.|:||.||:|||...:|:||:::|.....|..:.|::.|..|.||:::||..
Zfish   412 AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEM 476

  Fly   277 EPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANR 320
            :.:.|....|||:|.|::.||..|.|.|::   .|.:|..::||
Zfish   477 DVEKRGGGKELLQHPFLKLAKPLSSLTPLI---LAAKEAMKSNR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	98/256 (38%)
		S_TKc	42..293	CDD:214567	96/252 (38%)
		Mst1_SARAH	608..655	CDD:288481
pak2a	NP_001002717.1	PBD	74..129	CDD:279166
		STKc_PAK2	222..517	CDD:132986	107/299 (36%)
		S_TKc	242..493	CDD:214567	96/252 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910