Protein Alignment hpo and Map4k2

DIOPT Version :9

• Sequence 1: NP_001261092.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_033032.1
• Gene: Map4k2 / 26412
• MGIID: 1346883
• Length: 821
• Species: Mus musculus
• Alignment Length: 565
• Identity: 177/565 - (31%)
• Similarity: 270/565 - (47%)
• Gaps: 88/565 - (15%)

  Fly    35 LQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE--SDLHEIIKEISIMQQCDSPYV 97
            ||.|...|:::.::|.|:||.||||....:|.:.|:|:|.::  .|:..:.:||:|:::|..|.|
Mouse     9 LQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNV 73

  Fly    98 VRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDI 162
            |.|.|||.:...||||||:||.||:.:|.. ....|.|.:||.:..:.|:||.:||.:.||||||
Mouse    74 VAYIGSYLRNDRLWICMEFCGGGSLQEIYH-ATGPLEERQIAYVCREALKGLHHLHSQGKIHRDI 137

  Fly   163 KAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---EEIGYDCVADIWSLGI 224
            |.||:||..:|..|||||||:|:||.::|||.:.||||:||||||.   .:.||:.:.|:|:|||
Mouse   138 KGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGI 202

  Fly   225 TALEMAEGKPPYGEIHPMRAIFMIPQK--PPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATEL 287
            ||:|:.|.:||...:|||||:.::.:.  .||..|:..||:..|..|:...|.|.|..|.||..|
Mouse   203 TAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAERL 267

  Fly   288 LEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFME 352
            |:|.|  ..:|   |.|                            :|.||       :.|.|  .
Mouse   268 LQHPF--TTQH---LPP----------------------------ALLTQ-------LLDKA--S 290

  Fly   353 DP--GTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLR-NLSKAAAPAAASSAASPLDM 414
            ||  |||.||. .|.:.......|:.:.:..|..|.|  |..:: :..|..||....:  .||:.
Mouse   291 DPHLGTLSPED-SELETHDMFPDTIHSRSHHGPAERT--PSEIQFHQVKFGAPRRKET--DPLNE 350

  Fly   415 PAVDSGTMV---ELESNLGTMVINSDSDDSTTAK--------NNDDQKPRNRYRPQF--LEHFDR 466
            |..:..|::   ||..:|...|..:..:.|.|.:        ::.|.......|..|  |.|.:
Mouse   351 PWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRPALELQELDSPDDAIGTIKRAPFLGLPHTE- 414

  Fly   467 KNAGDGRGD------EKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQ 525
            ..:||....      ..|.|...|||.........:||:.:::...|.......:     :|...
Mouse   415 STSGDNAQSCSPGTLSAPPAGPGSPALLPTAWATLKQQEDRERSSCHGLPPTPKV-----HMGAC 474

  Fly   526 FQQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSN 570
            |.::  .|...||.|   ..|...:|:..:|.:.:..:..:...|
Mouse   475 FSKV--FNGCPLQIH---AAVTWVHPVTRDQFLVVGAEEGIYTLN 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	115/261 (44%)
		S_TKc	42..293	CDD:214567	114/257 (44%)
		Mst1_SARAH	608..655	CDD:288481
Map4k2	NP_033032.1	STKc_MAP4K3_like	16..272	CDD:270788	114/256 (45%)
		S_TKc	16..272	CDD:214567	114/256 (45%)
		PEST1	294..314		6/20 (30%)
		PEST2	344..360		4/17 (24%)
		PEST3	405..449		10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..442		9/33 (27%)
		CNH	489..801	CDD:214481	4/26 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910