DRSC/TRiP Functional Genomics Resources

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Protein Alignment hpo and Map3k3

DIOPT Version :9

Sequence 1:NP_001261092.1 Gene:hpo / 37247 FlyBaseID:FBgn0261456 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_036077.1 Gene:Map3k3 / 26406 MGIID:1346874 Length:626 Species:Mus musculus


Alignment Length:259 Identity:98/259 - (37%)
Similarity:132/259 - (50%) Gaps:19/259 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 LGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEIS-------IMQQCDSPYVVRYYGSYF 105
            ||:|::|.||.....::...:|.|.|..:.|..|..||:|       :::......:|:|||...
Mouse   368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLR 432

  Fly   106 KQYD--LWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANIL 168
            .:.:  |.|.|||...|||.|.:: ....|||..........|:|:.|||....:|||||.||||
Mouse   433 DRAEKILTIFMEYMPGGSVKDQLK-AYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANIL 496

  Fly   169 LNTEGYAKLADFGVAGQLTDTMAKRNT----VIGTPFWMAPEVIEEIGYDCVADIWSLGITALEM 229
            .::.|..||.|||.:.:| .|:....|    |.|||:||:||||...||...||:||||.|.:||
Mouse   497 RDSAGNVKLGDFGASKRL-QTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEM 560

  Fly   230 AEGKPPYGEIHPMRAIFMIPQKPP-PSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEF 292
            ...|||:.|...|.|||.|..:|. |..  |...|....||:.:..| |...|.:|.|||.|.|
Mouse   561 LTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hpoNP_001261092.1 STKc_MST1_2 38..293 CDD:132943 98/259 (38%)
S_TKc 42..293 CDD:214567 98/259 (38%)
Mst1_SARAH 608..655 CDD:288481
Map3k3NP_036077.1 PB1_Mekk2_3 45..123 CDD:99726
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..184
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..273
STKc_MEKK3_like 361..621 CDD:270795 97/257 (38%)
S_TKc 362..621 CDD:214567 97/257 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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