DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Map3k1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_036075.2	Gene:	Map3k1 / 26401	MGIID:	1346872	Length:	1493	Species:	Mus musculus

Alignment Length:	273	Identity:	86/273 - (31%)
Similarity:	141/273 - (51%)	Gaps:	36/273 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KLGEGSYGSVYKAVHKESSSIVAIKLVP----VESDLHEII----KEISIMQQCDSPYVVRYYGS 103
            ::|.|::.|.|:|....:.:::|:|.|.    ..|:..|::    :||.:|...:.|.::|..|:
Mouse  1229 QIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGHLNHPNIIRMLGA 1293

  Fly   104 YFKQ--YDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAAN 166
            ..::  |:|:|  |:...|||:.::. :.....|..:.......|:||.|||..:.||||:|.||
Mouse  1294 TCEKSNYNLFI--EWMAGGSVAHLLS-KYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGAN 1355

  Fly   167 ILLNTEGY-AKLADFGVAGQLTDTMAKRNT--------VIGTPFWMAPEVI--EEIGYDCVADIW 220
            :|:::.|. .::||||.|.:|    |.:.|        ::||..:|||||:  ::.|..|  |:|
Mouse  1356 LLIDSTGQRLRIADFGAAARL----ASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSC--DVW 1414

  Fly   221 SLGITALEMAEGKPPY-GEIHP--MRAIFMIPQ-KPPPSFREPDRWSTEFIDFVSKCLVKEPDDR 281
            |:|...:|||..|||: .|.|.  :..||.|.. ...||.  |...|....|...:||..:|.||
Mouse  1415 SVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSI--PSHLSPGLRDVALRCLELQPQDR 1477

  Fly   282 ATATELLEHEFIR 294
            ..:.|||:|...|
Mouse  1478 PPSRELLKHPVFR 1490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	85/270 (31%)
		S_TKc	42..293	CDD:214567	85/270 (31%)
		Mst1_SARAH	608..655	CDD:288481
Map3k1	NP_036075.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..178
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..300
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..431
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..531
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..914
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	992..1066
		STKc_MEKK1	1223..1490	CDD:270800	85/271 (31%)
		S_TKc	1224..1489	CDD:214567	85/270 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910