DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and sid1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_593564.1	Gene:	sid1 / 2542746	PomBaseID:	SPAC9G1.09	Length:	471	Species:	Schizosaccharomyces pombe

Alignment Length:	482	Identity:	163/482 - (33%)
Similarity:	243/482 - (50%)	Gaps:	70/482 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVES---DLHEIIKEISIMQQCDSPYVVRYYGS 103
            :.::.|||.||:|.|:||....|..|:|||.:.:|:   |:.:|.:|:.::..|:|..|::|||.
pombe     9 YTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSNCNSSNVIQYYGC 73

  Fly   104 YFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANIL 168
            :...|.|||.||:...||||.::::.:  |.|..|:.||.:.|.||.|||.:.||||||||||||
pombe    74 FVDGYTLWILMEHMDGGSVSGLLKMGR--LNEQVISIILREVLYGLNYLHGQNKIHRDIKAANIL 136

  Fly   169 LNTE-GYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEG 232
            |::. |..||||||||.||::..::|:|.:|||||||||||::..|...||||||||||:|||.|
pombe   137 LSSSTGNVKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVIQQTSYGLAADIWSLGITAIEMANG 201

  Fly   233 KPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNA- 296
            .||...:||||.||.|||..||..  .|.:|..|.||||.||...|:.|.:|.|||:|.||::|
pombe   202 IPPRATMHPMRVIFEIPQSEPPKL--DDHFSPTFRDFVSCCLDLNPNMRWSAKELLQHPFIKSAG 264

  Fly   297 -------------------KHRSILKPMLEETCAIREQ--------------QRANRSFGGVLAA 328
                               ..:|:|:..:..|....|:              :...:|...||..
pombe   265 TVKDIIPLLVQKENKLFDDSDQSVLEETINNTLKPFEEPIAEGNADIEDWTFETVKKSDSTVLGN 329

  Fly   329 SQ--AKSLATQENGMQQ----HITDNAFMEDPGTLVP------EKFGEYQQSSASDATMIAHAEQ 381
            :.  ..|:.:.:|..:.    ...:...|.|..|..|      ||...|.:|..||..|..:.:.
pombe   330 TSIPKNSIISSQNKEELPSSIKYLEKTIMSDQATPHPFSKSLSEKGSSYHKSLTSDFAMKHYIKS 394

  Fly   382 GVDEGTLGPGGLRNLSKAAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKN 446
            .:....|..    .||.....:..|...|           .:.|:.||.:..:|..:.|:.....
pombe   395 TIRSMLLND----KLSATQRSSLESFYTS-----------FISLDKNLSSKFVNQITPDNRLHHK 444

  Fly   447 NDDQKPRNRYR-PQFLEHFDRKNAGDG 472
            ...:.|.::.. .::||..:::.:.:|
pombe   445 KQKRSPISQLLFSRWLEETEKRRSLNG 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	126/254 (50%)
		S_TKc	42..293	CDD:214567	126/254 (50%)
		Mst1_SARAH	608..655	CDD:288481
sid1	NP_593564.1	STKc_MST3_like	7..279	CDD:270786	129/273 (47%)
sid1	NP_593564.1	S_TKc	9..260	CDD:214567	126/254 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910