DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Pak5

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_006499571.1	Gene:	Pak5 / 241656	MGIID:	1920334	Length:	736	Species:	Mus musculus

Alignment Length:	277	Identity:	105/277 - (37%)
Similarity:	159/277 - (57%)	Gaps:	12/277 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHE------IIKEISIMQQCDSPY 96
            |.:..|...|:||||.|.|..|..|.:...||:|    :.||.:      :..|:.||:......
Mouse   462 PREYLDNFIKIGEGSTGIVCIATEKHTGKQVAVK----KMDLRKQQRRELLFNEVVIMRDYHHDN 522

  Fly    97 VVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRD 161
            ||..|.||....:||:.||:...|:::||:...:  :.|::|||:....|:.|.|||.:..||||
Mouse   523 VVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIATVCLSVLKALSYLHNQGVIHRD 585

  Fly   162 IKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITA 226
            ||:.:|||.::|..||:|||...|::..:.||.:::|||:|||||||..:.|....|||||||..
Mouse   586 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMV 650

  Fly   227 LEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHE 291
            :||.:|:|||....|::|:..|....||..::..:.|:....|:...||:||..||||.|||.|.
Mouse   651 IEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQELLGHP 715

  Fly   292 FIRNAKHRSILKPMLEE 308
            |::.|...|.:.|::.:
Mouse   716 FLKLAGPPSCIVPLMRQ 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	101/260 (39%)
		S_TKc	42..293	CDD:214567	100/256 (39%)
		Mst1_SARAH	608..655	CDD:288481
Pak5	XP_006499571.1	CRIB_PAK_like	26..72	CDD:238526
Pak5	XP_006499571.1	STKc_PAK5	443..734	CDD:132989	105/277 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910