DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and gck-3

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_507517.2	Gene:	gck-3 / 190400	WormBaseID:	WBGene00013355	Length:	596	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	141/447 - (31%)
Similarity:	211/447 - (47%)	Gaps:	71/447 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PNISSSCSFFKLKKLSEESLLQPPEK------VFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLV 73
            |.:||..:.......:..:.|.|.::      .:.:...:|.|:..:|:.|.....:..||||.:
Worm    75 PQVSSPIAAAAAASAALVAQLNPADRWPTEPSAYKLDESIGVGATATVFTAYCLPRNEKVAIKCI 139

  Fly    74 PVE---SDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKK---- 131
            .:|   :.:.|:..||..|.||:.|.||.||.|:..|.:||:.|.....||:.||::.:.|
Worm   140 NLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGK 204

  Fly   132 ------TLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDT- 189
                  .|.|..|||:|.:.|:||.|.||..:|||||||.||||..:|..::|||||:|.|..:
Worm   205 EQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSG 269

  Fly   190 -----MAKRNTVIGTPFWMAPEVIEEI-GYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMI 248
                 ...|:|.:|||.||||||:|:: |||..||||||||.|:|:|.|..||.:..||:.:.:.
Worm   270 GDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLT 334

  Fly   249 PQKPPPSF----REPDRWST---EFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPML 306
            .|..||:.    ...|::..   .|...:..||.|:|..|.||:|||::.|.:..|.:..|...|
Worm   335 LQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFKKGKDKKYLVHTL 399

  Fly   307 EETCAIREQQRANRSFGGVLAASQAKSLATQ------------ENGMQQHITDNAFMEDPGTLVP 359
            .|          |.:...|:|...:|.:|:.            |....|...|::.:||...
Worm   400 IE----------NLASVPVVAHHSSKKVASGKLRKDAHGNWEFEYDSPQESDDDSDLEDEER--- 451

  Fly   360 EKFGEYQQSSASDATMIAHAEQGVDEGTLG-PGGLRNLSKAAAPAAASSAASPLDMP 415
            ||..:...:|||.|            |..| .||....:.:.||:|.....:....|
Worm   452 EKKKKKASASASGA------------GAAGAAGGATGGAASGAPSAQEGGGATTPCP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	107/287 (37%)
		S_TKc	42..293	CDD:214567	107/277 (39%)
		Mst1_SARAH	608..655	CDD:288481
gck-3	NP_507517.2	STKc_OSR1_SPAK	106..386	CDD:270787	107/279 (38%)
gck-3	NP_507517.2	S_TKc	108..386	CDD:214567	107/277 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910