DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and flr-4

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_510508.1	Gene:	flr-4 / 181604	WormBaseID:	WBGene00001468	Length:	570	Species:	Caenorhabditis elegans

Alignment Length:	409	Identity:	103/409 - (25%)
Similarity:	171/409 - (41%)	Gaps:	85/409 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SVVDMKSPNISSSCSFFKLKKLSEESLLQPPEKVFDI-MYK----LGEGSYGSVYKAVHKESSSI 67
            :.|::|   :||..    |:.|.:...|..|.::..| .||    ||:|.:|:|.|  ....::.
Worm     8 NAVELK---LSSQL----LQWLDQRLPLGDPMRIPSIDSYKYIQDLGKGRFGTVCK--FSNGNTF 63

  Fly    68 VAIKLVPVESDLHEIIKEISIMQQC---------------DSPYVVRYYGSYFKQYDLWICMEYC 117
            ..:|.|.:....|....|..:..:.               |:..:|.:.|.|.....::|..||.
Worm    64 ETVKKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYL 128

  Fly   118 GAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRK--IHRDIKAANILLNTEGYAKLADF 180
            ..|||.|:  |.|:||.||.....|.:|::.|.|||....  |||||||||:|:.:....|||:|
Worm   129 PRGSVKDL--LVKETLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANF 191

  Fly   181 GVAGQLT-----------DTMAKRNTVIGTPFWMAPEVIEEI-------GYDCVADIWSLGITAL 227
            |:...|.           .|:..|.|::    ::||||:...       .|:..||||:||.|.:
Worm   192 GLVRDLAVDGFGIAIASEITLDFRATLL----YVAPEVLSSALGPGNRNAYELPADIWALGCTFI 252

  Fly   228 EMAEGKPP----YGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELL 288
            ||...:||    :|.|..:..:.:...|....         :.:.:.|:.||  |.......:::
Worm   253 EMLLKRPPHFEYFGHIDEIPKVLLGYAKSEDG---------KVLPYTSEVLV--PSSSNCVQKIV 306

  Fly   289 EHEFIRNAKHRS-------ILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHIT 346
            :..||::.:||.       .:|.:|::.....|:...:.....   ::...|.|...|    |..
Worm   307 DLVFIKSPEHRPNTHKLRIQIKKILDDDSESEEETDISHPISN---SNTDSSTAISHN----HSN 364

  Fly   347 DNAFMEDPGTLVPEKFGEY 365
            |.. :...||.:|.:..||
Worm   365 DRK-VGRAGTCLPIESMEY 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	79/298 (27%)
		S_TKc	42..293	CDD:214567	78/294 (27%)
		Mst1_SARAH	608..655	CDD:288481
flr-4	NP_510508.1	PKc_like	40..323	CDD:304357	81/301 (27%)
flr-4	NP_510508.1	S_TKc	40..323	CDD:214567	81/301 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48015
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100