Protein Alignment hpo and mig-15

DIOPT Version :9

• Sequence 1: NP_001261092.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001024973.1
• Gene: mig-15 / 181248
• WormBaseID: WBGene00003247
• Length: 1096
• Species: Caenorhabditis elegans
• Alignment Length: 630
• Identity: 184/630 - (29%)
• Similarity: 304/630 - (48%)
• Gaps: 108/630 - (17%)

  Fly    35 LQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIK-EISIMQQ-CDSPYV 97
            |:.|..:|:::..:|.|:||.|||..|.:::.:.|||::.:..|..:.|| ||::::: .....|
 Worm    14 LRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNV 78

  Fly    98 VRYYGSYFKQY--------DLWICMEYCGAGSVSDIMRLRK-KTLTEDEIATILSDTLQGLVYLH 153
            ..|||::.|:.        .||:.||:||:||::|:::..| .:|.|:.||.|..:.|:||.:||
 Worm    79 ATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLH 143

  Fly   154 LRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----EEIGY 213
            ..:.||||||..|:||......||.||||:.||..|:.:|||.||||:|||||||     .|..|
 Worm   144 QSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATY 208

  Fly   214 DCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEP 278
            |..:|:|||||||||||||.||..::|||||:|:||:.|||..:...:|:.:|..|:...|||:.
 Worm   209 DSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDY 273

  Fly   279 DDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQR-----ANRSFGGVLAASQAKSLATQE 338
            ..|.....||.|.||:...|...::..::|  .|...:|     |:..:.|    |:....:...
 Worm   274 HQRPYTGALLRHPFIKEQPHEQTIRHSIKE--HIDRNRRVKKDDADYEYSG----SEDDEPSPNN 332

  Fly   339 NGMQQHITDNAFMEDPGTLVP------EKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLS 397
            .|....|.|::   :..:::|      :.|.:.|:||.      ..||.|..:       ||.|.
 Worm   333 RGPSMGIRDDS---ESSSMIPMDNTLRKGFQKLQESSR------GFAEPGAQQ-------LRRLP 381

  Fly   398 KAAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYRPQFLE 462
            :..|||......|....|..:| :.|:|.           :..|..|.:.....|.:|.||  :.
 Worm   382 QQPAPAPFQYQQSRYVEPRRES-SEVKLR-----------AVSSRGAADGPRHSPASRPRP--VS 432

  Fly   463 HFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQ-HLASGANDLNNWEHNMEMQF 526
            |..|...     ...|.|...:..|..:::::.:::::::::.| |.|              |..
 Worm   433 HHQRSPQ-----QSHPAAPHLADLANYEKRRRSEREERRERERQAHHA--------------MPI 478

  Fly   527 QQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQP---NLLLSNAAPMG--------QQGIP 580
            .::||    .:...||.::       |:|.|:..:.:|   ::|.|..:.||        ::.:.
 Worm   479 ARVSA----SVPAPQQSRK-------MSEPLLITHVKPEDLDVLASELSKMGGHHNGRSREESMS 532

  Fly   581 AAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLKFLTFDDLNQRLCN 625
            ...||.||   :...:.:.:.....||.:......:|||...:.|
 Worm   533 PPPPAPPP---REASISSITDTIDVGELDNGADAEWDDLKDIMMN 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	115/270 (43%)
		S_TKc	42..293	CDD:214567	114/266 (43%)
		Mst1_SARAH	608..655	CDD:288481	4/18 (22%)
mig-15	NP_001024973.1	STKc_myosinIII_N_like	14..288	CDD:270785	116/273 (42%)
		S_TKc	21..288	CDD:214567	114/266 (43%)
		CNH	773..1076	CDD:214481

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910