Protein Alignment hpo and cst-1

DIOPT Version :9

• Sequence 1: NP_001261092.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001024575.2
• Gene: cst-1 / 180708
• WormBaseID: WBGene00017472
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 632
• Identity: 265/632 - (41%)
• Similarity: 346/632 - (54%)
• Gaps: 155/632 - (24%)

  Fly    28 KLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQC 92
            ||...:|.:|||:||||:.||||||||||:||:|:||..::|||.|||::||.||||||||||||
 Worm    21 KLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQC 85

  Fly    93 DSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRK 157
            .|.|||:|||||||..||||.||||||||:|||||.|:|.|:|.||:.:|.|||:||.|||..:|
 Worm    86 KSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKK 150

  Fly   158 IHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSL 222
            |||||||.||||||:|.||||||||||||||||||||||||||||||||||||||||..||||||
 Worm   151 IHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSL 215

  Fly   223 GITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATEL 287
            ||||:|||||:|||.:|||||||||||.||||:|::|:.||:||.||:..||:|:|::|.||..|
 Worm   216 GITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRL 280

  Fly   288 LEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFME 352
            .||.||:||....|::.|:::                    :|.|::..|
 Worm   281 CEHTFIKNAPGCDIMQLMIQD--------------------AQEKAILGQ--------------- 310

  Fly   353 DPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPLDMPAV 417
                                                            ||.||||.
 Worm   311 ------------------------------------------------APMAASSG--------- 318

  Fly   418 DSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYRPQFLEHFDRKNAGDGRGDEKPIATE 482
            :..|:  |...:.||:   |..:||..::.|:.......|.| :|..       ..|.|.| .:.
 Worm   319 NDATL--LSEGMSTMI---DGGESTLVQHKDNYVTAQSLRSQ-MESL-------RIGGEIP-KSA 369

  Fly   483 YSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQQHQQQQQVL 547
            |.|.::      :.....:.|...|.||.::...|      ..|.|......:.|...:...:.
 Worm   370 YIPGSS------KNGNSPRVQPPGHTASASDPSKN------QPFAQDGTGPNFQLGTSESSYKD- 421

  Fly   548 MAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLK 612
            .:|.:||.:                                ..|:|:.    ..|.|:|:||||:
 Worm   422 ASYNMMNTE--------------------------------AEYENRF----QRAVVDGDFEFLR 450

  Fly   613 FLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQ 659
            .:|.|:|.:|..::|.|||.||.:|.::|..|||||:|.:..|::.|
 Worm   451 NITLDELIRRKESLDSEMEEEIRELQRRYKTKRQPILDVIEIKKRLQ 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	190/254 (75%)
		S_TKc	42..293	CDD:214567	187/250 (75%)
		Mst1_SARAH	608..655	CDD:288481	22/46 (48%)
cst-1	NP_001024575.2	STKc_MST1_2	31..286	CDD:132943	190/254 (75%)
		S_TKc	35..286	CDD:214567	187/250 (75%)
		Mst1_SARAH	446..493	CDD:288481	22/46 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160739
Domainoid	1	1.000	396	1.000	Domainoid score	I380
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48420
Inparanoid	1	1.050	486	1.000	Inparanoid score	I790
Isobase	1	0.950	-	0	Normalized mean entropy	S1182
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247842at33208
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	1	1.000	-	-		otm14236
orthoMCL	1	0.900	-	-		OOG6_102280
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4601
SonicParanoid	1	1.000	-	-		X1715
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.880