Protein Alignment hpo and gck-1

DIOPT Version :10

• Sequence 1: NP_611427.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_505310.2
• Gene: gck-1 / 179274
• WormBaseID: WBGene00001526
• Length: 803
• Species: Caenorhabditis elegans
• Alignment Length: 635
• Identity: 205/635 - (32%)
• Similarity: 286/635 - (45%)
• Gaps: 166/635 - (26%)

  Fly     4 PEVTSV-VDMKSPNIS--SSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESS 65
            |...|| :::.||.:|  ......|:.|..|::....||.:|....::|.||:|.|||.:...:.
 Worm   143 PSSLSVDLNVMSPEVSPPKPAERRKVVKPIEDNSKLDPEVIFTKQERIGRGSFGEVYKGIDNRTG 207

  Fly    66 SIVAIKLVPV---ESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMR 127
            .:||||::.:   |.::.:|.:||.::.||||.||.:|:||:.|...|||.|||.|.||..|:.:
 Worm   208 RVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTK 272

  Fly   128 LRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAK 192
            ..|  |.|..||.||.:.|:||.|||..|||||||||||:|::..|..|:||||||||||:|:.|
 Worm   273 SGK--LDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKK 335

  Fly   193 RNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFR 257
            |.|.:|:|||||||:|::..||..||||||||||:|:|.|:||:.::||||.:|:||:.|||..
 Worm   336 RITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVL- 399

  Fly   258 EPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANRSF 322
            :..:||..|.:||..||.|:|::|.:|:.||:|:||:.||..|||..::|.....|.:.
 Worm   400 QGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILVDLIERAAEYRLRT------ 458

  Fly   323 GGVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGT 387
             ||                                          ||.||          :||.:
 Worm   459 -GV------------------------------------------SSDSD----------LDEDS 470

  Fly   388 LGPGGLRNLSKAAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKP 452
            .|.||                .|..|.|.| .|..|            |..||.|..:..|  :|
 Worm   471 DGGGG----------------TSKWDYPTV-RGPRV------------SADDDGTVRQRTD--RP 504

  Fly   453 RNRYRPQFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNN 517
            |        ...||::.....|......:....|.||       |.:..........||.|
 Worm   505 R--------AQVDRRSPSGSPGGTIVRGSPQVAAVAE-------QLRNSSVGSSGYGSGGN---- 550

  Fly   518 WEHNMEMQFQQISAINQYGL----QQHQQQQ----QVLMAYPLMNEQLIALNNQPNLLL----SN 570
                        ||.:||..    |.|....    .:.:..|         |..|...|    |.
 Worm   551 ------------SASSQYATSSLPQSHTASSGGATTITLGSP---------NGSPTSSLARTQSM 594

  Fly   571 AAPMGQQGIPAAA--------------PAQPPPAYQNQHMHTQSHAYVEG 606
            .:|.||:...|.:              .:|..|:..||| .|.|...|:|
 Worm   595 VSPSGQRSGSAQSWELERGNRPMSERVSSQVSPSKYNQH-RTSSSNGVQG 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_611427.1	STKc_MST1_2	38..293	CDD:132943	129/257 (50%)
		SARAH_Hpo	606..661	CDD:439183	1/1 (100%)
gck-1	NP_505310.2	STKc_MST3_like	183..455	CDD:270786	135/274 (49%)