DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and gck-2

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_504721.1	Gene:	gck-2 / 179072	WormBaseID:	WBGene00022603	Length:	829	Species:	Caenorhabditis elegans

Alignment Length:	421	Identity:	143/421 - (33%)
Similarity:	219/421 - (52%)	Gaps:	84/421 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVES-DLHEII-KEISIMQQCDSPYVVRY 100
            |...::::.::|.|:||.||||....|.|:.|:|:|.:|: |...:| :||.::::|..|.::.|
Worm    11 PADDYELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFAVIQQEIMVIRECSHPNIIAY 75

  Fly   101 YGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAA 165
            :|||.::..|||.|||||.||:.||..| ...|:|.:||.:..:||:||.|||...|||||||.|
Worm    76 FGSYIRRDRLWIVMEYCGGGSLQDIYHL-TGPLSELQIAFVCRETLRGLNYLHNMGKIHRDIKGA 139

  Fly   166 NILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV--IEEI-GYDCVADIWSLGITAL 227
            ||||::.|..||||||||.|:|.|:.||.:.||||:||||||  :|:. ||....|:|:.||||:
Worm   140 NILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMQCDVWATGITAI 204

  Fly   228 EMAEGKPPYGEIHPMRAIFMIPQK--PPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELL-E 289
            |:.|.:||..::|||:.::::.:.  .||..::..||:..|.|||.:||.|.|..|.:..:|| .
Worm   205 ELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWTPLFHDFVRQCLTKNPKKRPSPEKLLTS 269

  Fly   290 HEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFMEDP 354
            |.|:.                             |.|:|...:.|..:.||....:.|.
Worm   270 HPFVL-----------------------------GSLSARMTRDLLDKVNGAPTDVYDR------ 299

  Fly   355 GTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASP--LDMPA- 416
                       ...:..|.|   ..|..:|:               ||:..:..|:|  :.:||
Worm   300 -----------MSKTVDDLT---EEESDMDD---------------APSLLTPDAAPIRIGLPAH 335

  Fly   417 -----VDSGTMVELESNLGTMVINSDSDDST 442
                 :|:..:.:|.|:..|   :|:||..|
Worm   336 LNGLRLDARCLEQLSSSPNT---SSESDRRT 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	117/262 (45%)
		S_TKc	42..293	CDD:214567	116/258 (45%)
		Mst1_SARAH	608..655	CDD:288481
gck-2	NP_504721.1	STKc_MAP4K3_like	14..273	CDD:270788	116/259 (45%)
		S_TKc	15..273	CDD:214567	116/258 (45%)
		CNH	483..804	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910