Protein Alignment hpo and kin-18

DIOPT Version :9

• Sequence 1: NP_001261092.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001022767.1
• Gene: kin-18 / 175862
• WormBaseID: WBGene00002201
• Length: 982
• Species: Caenorhabditis elegans
• Alignment Length: 827
• Identity: 208/827 - (25%)
• Similarity: 336/827 - (40%)
• Gaps: 216/827 - (26%)

  Fly    12 MKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLV--- 73
            :|.|:|:   :.|..|         .||:.:..:.::|.||:|:||.|..|::...||||.:
 Worm    12 IKDPSIA---ALFSNK---------DPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFS 64

  Fly    74 ---PVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTE 135
               .||. .::|:||:|.:.....|::|.|...:.|....|:.|||| .||.:||:.:.:|.:.|
 Worm    65 GKQAVEK-WNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYC-IGSAADIVDVLRKGMRE 127

  Fly   136 DEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTP 200
            .|||.|.|.||..|.|||..::|||||||.||||:.....||||||.| .|.|   ...|.||||
 Worm   128 VEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSA-SLVD---PAQTFIGTP 188

  Fly   201 FWMAPEVI---EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSF-----R 257
            |:||||||   :|..|...|||||||||.:|:||.:||...::.|.|::.|.|..||:.     .
 Worm   189 FFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLFSMNAMSALYHIAQNDPPTLSPIDTS 253

  Fly   258 EPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAI---------- 312
            |...||.||:.|:.|||.|..::|.:|.|...|.||:.::....::.:::.|..:
 Worm   254 EQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYK 318

  Fly   313 -------------REQQRAN-------------RSFG--GVLAASQAKSL--------------- 334
                         :|....|             .|.|  |..|:|::.||
 Worm   319 KMRKLMYLDETEGKEGSEGNGASDDLDFHGNEANSIGRAGDSASSRSASLTSFRSMQSSGGAGLL 383

  Fly   335 -ATQENGMQQHI-------------TDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDE 385
             :|...|...::             |.:|....|   :|.:... ..|::...||.:|...|...
 Worm   384 VSTNTTGAMDNVHGSSGYGNGSSSTTSSARRRPP---IPSQMLS-STSTSGVGTMPSHGSVGASI 444

  Fly   386 GTLGPGGLRNLSK---AAAPAAASSAAS--------PLD-----------MP--AVDSGTMVELE 426
            ..:......:.|:   .:.|.:.|.::|        |||           ||  ||.........
 Worm   445 TAIAVNPTPSPSEPIPTSQPTSKSESSSILETAHDDPLDTSIRAPVKDLHMPHRAVKERIATLQN 509

  Fly   427 SNLGTM----VINSDSDDSTTAKNNDDQKPRNRYRPQF----LEHFDRKNAGDGR-------GDE 476
            ....|:    :||.:.::.|...|..:|..:.::..|.    |:.|:.:.|.|..       .:.
 Worm   510 HKFATLRSQRIINQEQEEYTKENNMYEQMSKYKHLRQAHHKELQQFEERCALDREQLRVKMDREL 574

  Fly   477 KPIATEYSPAA--------------------AEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHN 521
            :.:.|.||...                    .|::.::.:..|.|||.:.:   .|..|..:::|
 Worm   575 EQLTTTYSKEKMRVRCSQNNELDKRKKDIEDGEKKMKKTKNSQNQQQMKLY---SAQQLKEYKYN 636

  Fly   522 MEMQFQQISAINQYGLQQHQQQQQV------------------LMAYPLMNEQLIALNNQPNLLL 568
            .|.|..::.::|..........::|                  |.|.  :.::::....|.   |
 Worm   637 KEAQKTRLRSLNMPRSTYENAMKEVKADLNRVKDARENDFDEKLRAE--LEDEIVRYRRQQ---L 696

  Fly   569 SNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLKFLTFDDLNQ------RLCNID 627
            ||...:.:|      ........|.:.|.|: |..:..:.|..:.|....||:      |.....
 Worm   697 SNLHQLEEQ------LDDEDVNVQERQMDTR-HGLLSKQHEMTRDLEIQHLNELHAMKKRHLETQ 754

  Fly   628 HEME---------LEIEQLNKKY--NAKRQP----IVDAMNAKRKRQ 659
            ||.|         .:.::|.||:  .:::||    |.:|...|:.||
 Worm   755 HEAESASQNEYTQRQQDELRKKHAMQSRQQPRDLKIQEAQIRKQYRQ 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	114/268 (43%)
		S_TKc	42..293	CDD:214567	112/264 (42%)
		Mst1_SARAH	608..655	CDD:288481	15/67 (22%)
kin-18	NP_001022767.1	PKc_like	28..291	CDD:304357	114/268 (43%)
		S_TKc	30..289	CDD:214567	112/264 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910