DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and MAP4K5

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_006566.2	Gene:	MAP4K5 / 11183	HGNCID:	6867	Length:	846	Species:	Homo sapiens

Alignment Length:	516	Identity:	167/516 - (32%)
Similarity:	264/516 - (51%)	Gaps:	88/516 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ESLLQP--------PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE--SDLHEIIKEI 86
            |:.|:|        |::.::::.::|.|:||.||||.:..:..:.|:|::.:|  .|...|.:||
Human     2 EAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEI 66

  Fly    87 SIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVY 151
            .::::|....:|.|:|||..:..|||||||||.||:.||..: ...|:|.:||.:..:|||||.|
Human    67 FMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHV-TGPLSELQIAYVCRETLQGLAY 130

  Fly   152 LHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV--IEEI-GY 213
            ||.:.|:|||||.|||||...|..||||||||.::|.|:|||.:.||||:||||||  :|:. ||
Human   131 LHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGY 195

  Fly   214 DCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQK--PPPSFREPDRWSTEFIDFVSKCLVK 276
            :.:.|||::||||:|:.|.:||..::|||||:|::.:.  .||..::..:||:.|.:||...|.|
Human   196 NQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTK 260

  Fly   277 EPDDRATATELLEHEFI-RNAKHRSILKPMLEET--------------------CAIREQQRA-N 319
            .|..|.||..||.|.|: :....|::...:|::.                    ..||...|: |
Human   261 NPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTN 325

  Fly   320 RSFGGVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVD 384
            |:       ::|:..|::.|      .|....|.|  |..|.....:...:||...:......||
Human   326 RN-------ARAERTASEIN------FDKLQFEPP--LRKETEARDEMGLSSDPNFMLQWNPFVD 375

  Fly   385 EGTLGPGGLRNLSKAAAPAAASSAASPL-DMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNND 448
            ....|    ::.||.|.|       .|| ..|.:.|..    |.|.      .|.:.::|.|:..
Human   376 GANTG----KSTSKRAIP-------PPLPPKPRISSYP----EDNF------PDEEKASTIKHCP 419

  Fly   449 DQKPRNRYRPQFLEH---------FDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQ 500
            |.:.|   .||.|..         .:..:.|:|.|..| :.:|.:..:|:..|..:::.::
Human   420 DSESR---APQILRRQSSPSCGPVAETSSIGNGDGISK-LMSENTEGSAQAPQLPRKKDKR 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	118/261 (45%)
		S_TKc	42..293	CDD:214567	117/257 (46%)
		Mst1_SARAH	608..655	CDD:288481
MAP4K5	NP_006566.2	STKc_MAP4K5	10..277	CDD:270813	118/267 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..485		40/194 (21%)
		CNH	511..826	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910