Protein Alignment hpo and PAK4

DIOPT Version :10

• Sequence 1: NP_611427.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_005875.1
• Gene: PAK4 / 10298
• HGNCID: 16059
• Length: 591
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 101/277 - (36%)
• Similarity: 156/277 - (56%)
• Gaps: 12/277 - (4%)

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHE------IIKEISIMQQCDSPY 96
            |....|...|:||||.|.|..|..:.|..:||:|    :.||.:      :..|:.||:......
Human   317 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVK----KMDLRKQQRRELLFNEVVIMRDYQHEN 377

  Fly    97 VVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRD 161
            ||..|.||....:||:.||:...|:::||:...:  :.|::||.:....||.|..||.:..||||
Human   378 VVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHRD 440

  Fly   162 IKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITA 226
            ||:.:|||..:|..||:|||...|::..:.:|.:::|||:|||||:|..:.|....|||||||..
Human   441 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505

  Fly   227 LEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHE 291
            :||.:|:|||....|::|:.||....||..:...:.|.....|:.:.||::|..||||.|||:|.
Human   506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHP 570

  Fly   292 FIRNAKHRSILKPMLEE 308
            |:..|...:.:.|::.:
Human   571 FLAKAGPPASIVPLMRQ 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_611427.1	STKc_MST1_2	38..293	CDD:132943	98/260 (38%)
		SARAH_Hpo	606..661	CDD:439183
PAK4	NP_005875.1	CRIB_PAK_like	10..55	CDD:238526
		Linker	25..320		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..301
		GEF-interaction domain (GID)	298..323		1/5 (20%)
		STKc_PAK4	300..591	CDD:132988	101/277 (36%)