DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and map4k5

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001135521.1	Gene:	map4k5 / 100216063	XenbaseID:	XB-GENE-6037447	Length:	861	Species:	Xenopus tropicalis

Alignment Length:	688	Identity:	195/688 - (28%)
Similarity:	300/688 - (43%)	Gaps:	195/688 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE--SDLHEIIKEISIMQQC 92
            |.:.|.:.|:..|:::.::|.|:||.||||.:.::..:.|:|::.:|  .|...|.:||.::::|
Frog     9 SADILRKNPQHDFELVQRVGSGTYGDVYKARNLQTGELAAVKIIKLEQGDDFSLIQQEIFMVKEC 73

  Fly    93 DSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRK 157
            ....:|.|:|||..:..|||||||||.||:.||..: ...|||.:||.:..:|||||.|||.|.|
Frog    74 KHANIVAYFGSYLSREKLWICMEYCGGGSLQDIYHV-TGPLTECQIAYMCRETLQGLGYLHSRGK 137

  Fly   158 IHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV--IEEI-GYDCVADI 219
            :|||||.|||||...|..||||||||.::|.|:|||.:.||||:||||||  :|:. ||:.:.||
Frog   138 MHRDIKGANILLTDNGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDI 202

  Fly   220 WSLGITALEMAEGKPPYGEIHPMRAIFMIPQK--PPPSFREPDRWSTEFIDFVSKCLVKEPDDRA 282
            |::||||:|:||.:||..::|||||:|::.:.  .||..:|..:||..|.:||...|:|.|..|.
Frog   203 WAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPKLKEKMKWSQSFHNFVKVSLIKNPKKRP 267

  Fly   283 TATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITD 347
            .|..||.|:|        :::|.|....                    |:.|..:.|....|
Frog   268 PAERLLTHQF--------VVQPGLSRIV--------------------AQELLDKFNNPDSH--- 301

  Fly   348 NAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPL 412
                        ..:||.........:|:.|.             :|:.|||   |.|...||.|
Frog   302 ------------HHYGEPDDDDPEPLSMVRHT-------------IRSTSKA---ARAERTASEL 338

  Fly   413 DMPAV------------DSGTMVELESNLGTMVI---NSDSDDSTTAK----------------- 445
            :...:            :.|.....|::.|...|   |..::|||..|
Frog   339 NFDKLQFEPPLRKETEANEGMGCSRENDFGAQWISFANGANNDSTMKKAVPPPLPPKPVRMNSCP 403

  Fly   446 --NNDD--------QKPRNRYRPQF--------------LEH------------FDRKNAGDGRG 474
              |.||        .:..|| .|||              |.|            :..:|...|.|
Frog   404 DENMDDSERSSTIKHQQENR-APQFHRRQSSPGCGHQGALSHNVLTSSISSPGLYSSRNCDMGNG 467

  Fly   475 DEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASG-----------------------ANDLN 516
            | .|:.   || ..|..:.|..|:::::...:.:.:|                       .|...
Frog   468 D-SPVR---SP-IGEGGKPQLPQKKEKKDIPKSVINGLPPTPKVLMGACFSKVFDGCPLKINCAT 527

  Fly   517 NWEHNMEMQFQQISAINQYGL------QQHQQQQQVLMAYP-------LMNEQLIALNNQPNLLL 568
            :|.| .:.:.|.|...::.|:      :.|:...:.|  :|       :||..|::|:....:.|
Frog   528 SWIH-PDTKDQYIIFGSEDGIYTLNLNELHEATMEQL--FPRKCTWLYIMNNMLMSLSEGKTVQL 589

  Fly   569 SNAAPMG---QQGIPAAAPAQPPPAYQNQHMHTQSHAY 603
            .:...:|   |...|..|            .|.|:|.:
Frog   590 YSHNLVGLFEQAKKPGLA------------AHIQTHRF 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	122/261 (47%)
		S_TKc	42..293	CDD:214567	121/257 (47%)
		Mst1_SARAH	608..655	CDD:288481
map4k5	NP_001135521.1	STKc_MAP4K5	11..278	CDD:270813	124/275 (45%)
		S_TKc	21..278	CDD:214567	122/265 (46%)
		CNH	525..841	CDD:214481	20/106 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910