DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and stk24

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001123697.1	Gene:	stk24 / 100170450	XenbaseID:	XB-GENE-987144	Length:	424	Species:	Xenopus tropicalis

Alignment Length:	427	Identity:	170/427 - (39%)
Similarity:	243/427 - (56%)	Gaps:	54/427 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQCD 93
            :||...||::|..:.|:|:||:|.|:|.:...:..:||||::.:   |.::.:|.:||:::.|||
Frog    14 QSLKADPEELFRKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

  Fly    94 SPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKI 158
            ||||.:|||||.|...|||.|||.|.||..|:  |....|.|.:|||||.:.|:||.|||..:||
Frog    79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL--LEPGPLDETQIATILREILKGLDYLHSEKKI 141

  Fly   159 HRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLG 223
            ||||||||:||:..|..||||||||||||||..||||.:|||||||||||::..||..|||||||
Frog   142 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLG 206

  Fly   224 ITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELL 288
            |||:|:|:|:||:.|:|||:.:|:||:..||:..  ..:|....:||..||.|||..|.:|.|||
Frog   207 ITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLE--GNYSKGLKEFVEACLNKEPSFRPSAKELL 269

  Fly   289 EHEFI-RNAKHRSILKPML------------EETCAIREQQRANRSFGG-------VLAASQAKS 333
            :|:|| |:||..|.|..::            |.:.:..|::..:::.|.       .......|:
Frog   270 KHKFIMRSAKKTSYLTELIDRYKRWKIEQGHEASSSDSEEEEVDQAAGSEKDYWNFTRRKRDLKN 334

  Fly   334 L----ATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLR 394
            |    |..|.  .:.|......:...|::...|.|.::.|.:....:...|:           ||
Frog   335 LEPIPAQPEE--VKDIPKRPLSQCLSTIMSPLFAELKEKSQACGGNVGSIEE-----------LR 386

  Fly   395 N---LSKAAAPAAASSAASPL-------DMPAVDSGT 421
            .   |::.|.|..:.|..|.|       .:..|||.:
Frog   387 EAIYLAEEACPGISDSMVSQLLIRLQRYSVNGVDSSS 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	137/257 (53%)
		S_TKc	42..293	CDD:214567	135/253 (53%)
		Mst1_SARAH	608..655	CDD:288481
stk24	NP_001123697.1	STKc_MST3	19..295	CDD:270809	144/279 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D967913at2759
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010