DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and mink1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_021331645.1	Gene:	mink1 / 100038799	ZFINID:	ZDB-GENE-060526-45	Length:	1314	Species:	Danio rerio

Alignment Length:	668	Identity:	200/668 - (29%)
Similarity:	301/668 - (45%)	Gaps:	136/668 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV-ESDLHEIIKEISIMQQCDSPY-- 96
            |:.|..:|:::..:|.|:||.|||..|.::..:.|||::.| |.:..||..||:::::    |
Zfish    18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEEEEEEIKAEINMLKK----YSH 78

  Fly    97 ---VVRYYGSYFKQ----YD--LWICMEYCGAGSVSDIMRLRK-KTLTEDEIATILSDTLQGLVY 151
               :..|||::.|:    :|  ||:.||:||||||:|:::..| .:|.||.||.|..:.|:||.:
Zfish    79 HRNIATYYGAFVKKSPPGHDDQLWLVMEFCGAGSVTDLVKNTKGNSLKEDWIAYICREILRGLSH 143

  Fly   152 LHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----EEI 211
            ||..:.||||||..|:||......||.||||:.||..|:.:|||.||||:|||||||     .:.
Zfish   144 LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDS 208

  Fly   212 GYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVK 276
            .||..:|||||||||:|||||.||..::|||||:|:||:.|||..:. .:||.:||||:..||||
Zfish   209 TYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKS-KKWSKKFIDFIEGCLVK 272

  Fly   277 EPDDRATATELLEHEFIRN----AKHRSILKPMLEETCAIR-EQQRANRSFGGVLAASQAKSLAT 336
            ...:|.:..:||:|.|||:    .:.|..||..::.|...| |::.....:.|        |...
Zfish   273 SYPNRPSTEQLLKHSFIRDQPTERQVRIQLKDHIDRTRKKRGEKEETEYEYSG--------SDEE 329

  Fly   337 QENGMQQHITDNAFMEDPG-TLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAA 400
            .||...:. ..::.:..|| :.:...|...||.:                        :..|:|.
Zfish   330 DENRGDER-ESSSILNVPGESTLRRDFLRLQQEN------------------------KERSEAL 369

  Fly   401 APAAASSAASPLDMPAV-------DSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYRP 458
            ....|..||...| |..       |....:|.:......:......:....:...|:.|..|..
Zfish   370 KRQQAQLAAQRRD-PEEHKRQLLHDRQKRIEEQKEQRRRLEEQQRKEREMVRQQQDKAPHRRLD- 432

  Fly   459 QFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLA---------SGAND 514
                  |.:...|.|..|:  ..|:.....|::|:|.:..|||...||.|.         |..|:
Zfish   433 ------DMRREEDRRLAER--EQEFIRHKLEEEQRQLEILQQQLLQEQALLMLYNKHCSDSSVNE 489

  Fly   515 LNNWE-------HNMEMQFQQISAINQYGLQQHQQQQ--QVLMAYPLMN------------EQLI 558
            ....:       ..::.|.||..|. ...|||.||||  :..|.:...|            |:..
Zfish   490 YKRKQLEEQRQSERLQRQLQQEHAY-LVSLQQQQQQQDKKPQMYHYSKNLENNKPAWAREVEERS 553

  Fly   559 ALNNQ--PNL--------LLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLKF 613
            .||.|  |.:        :.|.:..:.|.|.....|.|.|...|..          :|:|:....
Zfish   554 KLNRQGSPKICTTVSDTNIQSRSESINQSGAAQTPPMQRPVEPQGG----------QGKFQMAHL 608

  Fly   614 LTFDDL------NQRLCN 625
            :.....      :|.||:
Zfish   609 VPLKPYAAPVPRSQSLCD 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	123/272 (45%)
		S_TKc	42..293	CDD:214567	122/268 (46%)
		Mst1_SARAH	608..655	CDD:288481	4/24 (17%)
mink1	XP_021331645.1	STKc_MAP4K4_6_N	8..289	CDD:270806	124/275 (45%)
mink1	XP_021331645.1	CNH	996..1294	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910