DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rep and GDI2

DIOPT Version :9

Sequence 1:	NP_477420.1	Gene:	Rep / 37246	FlyBaseID:	FBgn0026378	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001485.2	Gene:	GDI2 / 2665	HGNCID:	4227	Length:	445	Species:	Homo sapiens

Alignment Length:	497	Identity:	122/497 - (24%)
Similarity:	211/497 - (42%)	Gaps:	101/497 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EQFDLVVIGTGFTESCIAAAGSRIGKSVLHLDSNEYYGDVWSSFS-MDALCARLDQEVEPHSALR 70
            |::|::|:|||.||..::...|..||.|||:|.|.|||...:|.: ::.|..|......|..::.
Human     3 EEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPGSPPESMG 67

  Fly    71 NARYTWHSMEKESETDAQSWNRDSVLAKSRRFSLDLCPRILYAAGELVQLLIKSNICRYAEFRAV 135
            ..|               .||            :||.|:.|.|.|:||::|:.:.:.||.:|:..
Human    68 RGR---------------DWN------------VDLIPKFLMANGQLVKMLLYTEVTRYLDFKVT 105

  Fly   136 DHVCMRHNGEIVSVPCSRSDVFNTKTLTIVEKRLLMKFLTACNDYGEDKCNEDSLEFRG-----R 195
            :...:...|:|..||.:.::...:..:.:.|||...|||....::.|    :|...|.|     .
Human   106 EGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDE----KDPRTFEGIDPKKT 166

  Fly   196 TFLEYLQAQRVTEKISSCVMQAIAMCGPSTSFE----EGMQRTQRFLGSLGRYGNTPFLFPMYGC 256
            |..:..:...:.:.:......|:|:.......:    |.:.|.:.:..||.|||.:|:|:|:||.
Human   167 TMRDVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGL 231

  Fly   257 GELPQCFCRLCAVYGGIYCLKRAVDDIALDSNSNEFLLSSAGKTLRAKNVVSAPGYTPVSKGIEL 321
            |||||.|.||.|:|||.|.|.:.:::|.: .|.....:.|.|:..|.|.::..|.|  |...:|.
Human   232 GELPQGFARLSAIYGGTYMLNKPIEEIIV-QNGKVIGVKSEGEIARCKQLICDPSY--VKDRVEK 293

  Fly   322 KPHISRGLFISSSPLGNEELNKGGGGVNLLRLL--DNEGGREA----FLIQLSHYTGACPEGLYI 380
            ...:.|.:.|.|.|:      |.....|..:::  .|:..|::    .:|..:|...|  :|.||
Human   294 VGQVIRVICILSHPI------KNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAA--QGKYI 350

  Fly   381 FHLTT------------PALS------------------EDPASDLAIFTSQLFDQSDAQIIFSS 415
            ..::|            |||.                  :|..::..||.|:.:|.       ::
Human   351 AIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDA-------TT 408

  Fly   416 YFTIAAQSSKSPAAEHIYYTDPPTYELDYDAAIANARDIFGK 457
            :|.......|:      .|......|.|::.......||:|:
Human   409 HFETTCDDIKN------IYKRMTGSEFDFEEMKRKKNDIYGE 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rep	NP_477420.1	NADB_Rossmann	4..397	CDD:304358	110/435 (25%)
GDI2	NP_001485.2	GDI	1..436	CDD:366408	119/487 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810