Protein Alignment Tbcb and CLIP4

DIOPT Version :10

• Sequence 1: NP_611425.1
• Gene: Tbcb / 37244
• FlyBaseID: FBgn0034451
• Length: 244
• Species: Drosophila melanogaster
• Sequence 2: NP_078968.3
• Gene: CLIP4 / 79745
• HGNCID: 26108
• Length: 705
• Species: Homo sapiens
• Alignment Length: 181
• Identity: 51/181 - (28%)
• Similarity: 76/181 - (41%)
• Gaps: 36/181 - (19%)

  Fly    51 CAGTMKVQVFKGDTCVSTMDNNDAQLGYYANSDGLRLHVVDSFATFSFDSAPVEKFELSKDQYEQ 115
            |||.:|..:.:|.......|..........:...:.|.:.|:.||             :|:..:.
Human   199 CAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPLEMADAAAT-------------AKEIKQM 250

  Fly   116 RTDSVRNYLKINR--MGKYNDEEMQQAEEKKRLQAEEIQKRAELCVLGGRC--EVTVPGNPTRRG 176
            ..|:|.....|::  :..|                :.:..:|.|..||.:.  .|.:.|.  :.|
Human   251 LLDAVPLSCNISKAMLPNY----------------DHVTGKAMLTSLGLKLGDRVVIAGQ--KVG 297

  Fly   177 TIRYNGPLEGKSGHFIGVEYDEPLGKNNGSFGGKAYFTCAPNYGGFVSPLS 227
            |:|:.|..|..||.:.|:|.|||.||||||.|...||.|||.||.| :|||
Human   298 TLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIF-APLS 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbcb	NP_611425.1	Ubiquitin_2	13..93	CDD:405277	8/41 (20%)
		CAP_GLY	160..225	CDD:460154	31/66 (47%)
CLIP4	NP_078968.3	ANK 1	65..101
		ANKYR	<84..>225	CDD:440430	6/25 (24%)
		ANK repeat	109..146	CDD:293786
		ANK 2	149..180
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786	5/17 (29%)
		ANK 3	186..215		5/15 (33%)
		CAP_GLY	285..349	CDD:460154	32/66 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..410
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..479
		CAP_GLY	487..551	CDD:460154
		CAP_GLY	626..690	CDD:460154