DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBCB and Tbcb

DIOPT Version :9

Sequence 1:	NP_611425.1	Gene:	TBCB / 37244	FlyBaseID:	FBgn0034451	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_001035270.1	Gene:	Tbcb / 292777	RGDID:	1309965	Length:	244	Species:	Rattus norvegicus

Alignment Length:	237	Identity:	101/237 - (42%)
Similarity:	148/237 - (62%)	Gaps:	11/237 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKVNVSNSHNDAVAFEVKLAKDLTVAQLKTKLEILTGGCAGTMKVQVF-KGDTCVSTMDNNDAQL 76
            :.|.:|:|.| :...|.:.::.||:|:.|.|||::.|..|..|::::: ..|...|.:|..||.|
  Rat    11 VTVFISSSLN-SFRSEKRYSRSLTIAEFKCKLELVVGSPASCMELELYGADDQFYSKLDQEDALL 74

  Fly    77 GYYANSDGLRLHVVD----SFATFSFDSAPVEKFELSKDQYEQRTDSVRNYLKINRMGKYNDE-- 135
            |.|...||.|:||:|    ....:. |.:.|||:|:|.:.||:|.::||:::|.:::|.||:|
  Rat    75 GSYPVDDGCRIHVIDHSGVRLGEYE-DVSKVEKYEISPEAYERRQNTVRSFMKRSKLGPYNEELR 138

  Fly   136 EMQQAEEKKRLQAEEIQKRAELCVLGGRCEVTVPGNPTRRGTIRYNGPLEGKSGHFIGVEYDEPL 200
            ..|:||..:||..||.|  |....:|.||||..||...||||:.|.|..:.|.|:::||.|||||
  Rat   139 AQQEAEAAQRLSEEEAQ--ASAISVGSRCEVRAPGQSLRRGTVMYVGLTDFKPGYWVGVRYDEPL 201

  Fly   201 GKNNGSFGGKAYFTCAPNYGGFVSPLSVTVGDFPPEDFNMDD 242
            |||:||..||.||.|...||.||.|.:|||||||.||:.:|:
  Rat   202 GKNDGSVNGKRYFECQAKYGAFVKPAAVTVGDFPEEDYGLDE 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBCB	NP_611425.1	Alp11_N	12..95	CDD:176384	29/86 (34%)
TBCB	NP_611425.1	CAP_GLY	161..225	CDD:279625	36/63 (57%)
Tbcb	NP_001035270.1	Ubl_TBCB	11..89	CDD:340487	28/78 (36%)
Tbcb	NP_001035270.1	CAP_GLY	161..229	CDD:396049	37/67 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346061
Domainoid	1	1.000	74	1.000	Domainoid score	I9003
eggNOG	1	0.900	-	-		E1_KOG3206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3810
OMA	1	1.010	-	-		QHG54068
OrthoDB	1	1.010	-	-		D1550378at2759
OrthoFinder	1	1.000	-	-		FOG0003696
OrthoInspector	1	1.000	-	-		oto96415
orthoMCL	1	0.900	-	-		OOG6_102852
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4116
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.710