DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBCB and tbcb-1

DIOPT Version :9

Sequence 1:	NP_611425.1	Gene:	TBCB / 37244	FlyBaseID:	FBgn0034451	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_506367.1	Gene:	tbcb-1 / 186176	WormBaseID:	WBGene00009987	Length:	229	Species:	Caenorhabditis elegans

Alignment Length:	250	Identity:	93/250 - (37%)
Similarity:	129/250 - (51%)	Gaps:	42/250 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IETGKSDFIKVNVSNSHNDAVAFEVKLAKDLTVAQLKTKLEILTGGCAGTMKVQVFKGDTCVSTM 69
            |.|..:||             ..|.|....:::..||.|||::.|....:|::|:|.||
Worm     9 ITTNATDF-------------PMEKKYPAGMSLNDLKKKLELVVGTTVDSMRIQLFDGD------ 54

  Fly    70 DNNDAQLGYYANS-------DGLRLHVVD-SFATFSF-DSAPVEKFELSKDQYEQRTDSVRNYLK 125
            |....:|...|.|       ||.|:|.|| :.....| |.:.|||:|:|.|.|.:||||||.:.|
Worm    55 DQLKGELTDGAKSLKDLGVRDGYRIHAVDVTGGNEDFKDESMVEKYEMSDDTYGKRTDSVRAWKK 119

  Fly   126 INRMGKYNDEEMQQA---EEKKRLQAEEIQKRAELCVLGGRCEVTVPGNPTRRGTIRYNGPLEGK 187
                 |..:|:...|   .|..:|..|    .|:..::|.||||||.....|||.:.|.|..:.|
Worm   120 -----KMQEEQGSAAPMENESDKLNEE----AAKNIMVGNRCEVTVGAQMARRGEVAYVGATKFK 175

  Fly   188 SGHFIGVEYDEPLGKNNGSFGGKAYFTCAPNYGGFVSPLSVTVGDFPPEDFNMDD 242
            .|.::||:||||:|||:||..|..||.|.|.|||||.|:.|.|||||  :.::|:
Worm   176 EGVWVGVKYDEPVGKNDGSVAGVRYFDCDPKYGGFVRPVDVKVGDFP--ELSIDE 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBCB	NP_611425.1	Alp11_N	12..95	CDD:176384	24/90 (27%)
TBCB	NP_611425.1	CAP_GLY	161..225	CDD:279625	35/63 (56%)
tbcb-1	NP_506367.1	Alp11_N	4..87	CDD:176384	27/96 (28%)
tbcb-1	NP_506367.1	CAP_GLY	149..216	CDD:279625	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3206
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H981
Inparanoid	1	1.050	139	1.000	Inparanoid score	I3085
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54068
OrthoDB	1	1.010	-	-		D1550378at2759
OrthoFinder	1	1.000	-	-		FOG0003696
OrthoInspector	1	1.000	-	-		oto18150
orthoMCL	1	0.900	-	-		OOG6_102852
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R50
SonicParanoid	1	1.000	-	-		X4116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770