DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBCB and TBCB

DIOPT Version :9

Sequence 1:	NP_611425.1	Gene:	TBCB / 37244	FlyBaseID:	FBgn0034451	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_001272.2	Gene:	TBCB / 1155	HGNCID:	1989	Length:	244	Species:	Homo sapiens

Alignment Length:	236	Identity:	105/236 - (44%)
Similarity:	148/236 - (62%)	Gaps:	9/236 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKVNVSNSHNDAVAFEVKLAKDLTVAQLKTKLEILTGGCAGTMKVQVF-KGDTCVSTMDNNDAQL 76
            :.|.:|:|.| ....|.:.::.||:|:.|.|||:|.|..|..|::::: ..|...|.:|..||.|
Human    11 VTVFISSSLN-TFRSEKRYSRSLTIAEFKCKLELLVGSPASCMELELYGVDDKFYSKLDQEDALL 74

  Fly    77 GYYANSDGLRLHVVD-SFATFS--FDSAPVEKFELSKDQYEQRTDSVRNYLKINRMGKYNDEE-- 136
            |.|...||.|:||:| |.|...  .|.:.|||:.:|::.|:||.|:||::||.:::|:||:||
Human    75 GSYPVDDGCRIHVIDHSGARLGEYEDVSRVEKYTISQEAYDQRQDTVRSFLKRSKLGRYNEEERA 139

  Fly   137 MQQAEEKKRLQAEEIQKRAELCVLGGRCEVTVPGNPTRRGTIRYNGPLEGKSGHFIGVEYDEPLG 201
            .|:||..:||..|:.|  |....:|.||||...|...||||:.|.|..:.|.|::|||.||||||
Human   140 QQEAEAAQRLAEEKAQ--ASSIPVGSRCEVRAAGQSPRRGTVMYVGLTDFKPGYWIGVRYDEPLG 202

  Fly   202 KNNGSFGGKAYFTCAPNYGGFVSPLSVTVGDFPPEDFNMDD 242
            ||:||..||.||.|...||.||.|..|||||||.||:.:|:
Human   203 KNDGSVNGKRYFECQAKYGAFVKPAVVTVGDFPEEDYGLDE 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBCB	NP_611425.1	Alp11_N	12..95	CDD:176384	31/83 (37%)
TBCB	NP_611425.1	CAP_GLY	161..225	CDD:279625	36/63 (57%)
TBCB	NP_001272.2	Ubiquitin_2	11..93	CDD:373130	31/83 (37%)
TBCB	NP_001272.2	CAP_GLY	161..226	CDD:366568	36/64 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152544
Domainoid	1	1.000	72	1.000	Domainoid score	I9415
eggNOG	1	0.900	-	-		E1_KOG3206
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H981
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3933
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54068
OrthoDB	1	1.010	-	-		D1550378at2759
OrthoFinder	1	1.000	-	-		FOG0003696
OrthoInspector	1	1.000	-	-		oto89292
orthoMCL	1	0.900	-	-		OOG6_102852
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R50
SonicParanoid	1	1.000	-	-		X4116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.700